Generation of Aurachin Derivatives by Whole-Cell Biotransformation and Evaluation of Their Antiprotozoal Properties

Generation of Aurachin Derivatives by Whole-Cell Biotransformation and Evaluation of Their Antiprotozoal Properties

The natural product aurachin D is a farnesylated quinolone alkaloid, which is known to possess activity against the causative agent of malaria, <i>Plasmodium</i> spp. In this study, we show that aurachin D inhibits other parasitic protozoa as well. While aurachin D had only a modest effe...

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Bibliographic Details
Main Authors: Sebastian Kruth, Cindy J.-M. Zimmermann, Katharina Kuhr, Wolf Hiller, Stephan Lütz, Jörg Pietruszka, Marcel Kaiser, Markus Nett
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
antiprotozoal
aurachin
biotransformation
<i>Escherichia coli</i>
quinoline
quinolone
Online Access:https://www.mdpi.com/1420-3049/28/3/1066

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