The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review
Sepsis is defined as "an organic dysfunction secondary to the dysregulated response of the patient to an infection." This concept only reveals the tip of the iceberg, the clinical expression of organic failures, without understanding their basis, which is currently explained by cellular a...
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| Format: | Article |
| Language: | English |
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Universidad Nacional Hermilio Valdizán de Huánuco
2023-02-01
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| Series: | Microbes, Infection and Chemotherapy |
| Subjects: | |
| Online Access: | https://revistas.unheval.edu.pe/index.php/mic/article/view/1595 |
| _version_ | 1828035731616956416 |
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| author | Jorge Luis Vélez Paez Fernando E. Rueda-Barragán Sarahí Dueñas-Andrade Alfonso Rodrigez-Morales Nikolaos C. Kyriakidis |
| author_facet | Jorge Luis Vélez Paez Fernando E. Rueda-Barragán Sarahí Dueñas-Andrade Alfonso Rodrigez-Morales Nikolaos C. Kyriakidis |
| author_sort | Jorge Luis Vélez Paez |
| collection | DOAJ |
| description |
Sepsis is defined as "an organic dysfunction secondary to the dysregulated response of the patient to an infection." This concept only reveals the tip of the iceberg, the clinical expression of organic failures, without understanding their basis, which is currently explained by cellular and molecular phenomena. Neutrophils are crucial pillars of early innate immune responses, and their fundamental function is phagocytosis. Additionally, neutrophils can degranulate upon activation, releasing various antimicrobial enzymes and pro-inflammatory cytokines, and form neutrophil extracellular traps (NETs), whose purpose is to trap pathogens by releasing their "sticky" nuclear content; the presence of activated platelets amplifies this phenomenon. NETosis is a beneficial process; however, deregulated, it can be detrimental, inducing "immunothrombosis" and compromising the microcirculation, thereby increasing the clinical severity of sepsis. The purpose of this review is to clearly describe the pathophysiological role therapeutic target of NETs, their interaction with platelets in sepsis, and their potential as therapeutic targets, since it has been shown that a therapeutic approach aimed at curbing NETs would be beneficial.
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| first_indexed | 2024-04-10T15:50:44Z |
| format | Article |
| id | doaj.art-7a8fb9c9ec674afa923832260cdaf5f4 |
| institution | Directory Open Access Journal |
| issn | 2789-4274 |
| language | English |
| last_indexed | 2024-04-10T15:50:44Z |
| publishDate | 2023-02-01 |
| publisher | Universidad Nacional Hermilio Valdizán de Huánuco |
| record_format | Article |
| series | Microbes, Infection and Chemotherapy |
| spelling | doaj.art-7a8fb9c9ec674afa923832260cdaf5f42023-02-11T23:09:08ZengUniversidad Nacional Hermilio Valdizán de HuánucoMicrobes, Infection and Chemotherapy2789-42742023-02-01310.54034/mic.e1595The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature reviewJorge Luis Vélez Paez0Fernando E. Rueda-Barragán1Sarahí Dueñas-Andrade2Alfonso Rodrigez-Morales3Nikolaos C. Kyriakidis4Facultad de Ciencias Medicas, Universidad Central del Ecuador, Quito, EcuadorFacultad de Ciencias Medicas, Universidad Central del Ecuador, Quito, EcuadorFacultad de Ciencias Medicas, Universidad Central del Ecuador, Quito, EcuadorFundación Universitaria Autónoma de las Américas-Institución Universitaria Visión de las Américas, Pereira, Risaralda, ColombiaUniversidad de las Américas, Quito, Ecuador Sepsis is defined as "an organic dysfunction secondary to the dysregulated response of the patient to an infection." This concept only reveals the tip of the iceberg, the clinical expression of organic failures, without understanding their basis, which is currently explained by cellular and molecular phenomena. Neutrophils are crucial pillars of early innate immune responses, and their fundamental function is phagocytosis. Additionally, neutrophils can degranulate upon activation, releasing various antimicrobial enzymes and pro-inflammatory cytokines, and form neutrophil extracellular traps (NETs), whose purpose is to trap pathogens by releasing their "sticky" nuclear content; the presence of activated platelets amplifies this phenomenon. NETosis is a beneficial process; however, deregulated, it can be detrimental, inducing "immunothrombosis" and compromising the microcirculation, thereby increasing the clinical severity of sepsis. The purpose of this review is to clearly describe the pathophysiological role therapeutic target of NETs, their interaction with platelets in sepsis, and their potential as therapeutic targets, since it has been shown that a therapeutic approach aimed at curbing NETs would be beneficial. https://revistas.unheval.edu.pe/index.php/mic/article/view/1595sepsisNETsplatelets |
| spellingShingle | Jorge Luis Vélez Paez Fernando E. Rueda-Barragán Sarahí Dueñas-Andrade Alfonso Rodrigez-Morales Nikolaos C. Kyriakidis The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review Microbes, Infection and Chemotherapy sepsis NETs platelets |
| title | The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review |
| title_full | The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review |
| title_fullStr | The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review |
| title_full_unstemmed | The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review |
| title_short | The role of platelets and neutrophil extracellular traps (NETs) in sepsis: A comprehensive literature review |
| title_sort | role of platelets and neutrophil extracellular traps nets in sepsis a comprehensive literature review |
| topic | sepsis NETs platelets |
| url | https://revistas.unheval.edu.pe/index.php/mic/article/view/1595 |
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