Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy

Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy

Summary: A comprehensive understanding of the phenotype of persistent HIV-infected cells, transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure. The relevance of cell-surface glycosylation to HIV persistence has never been explored. We characterize the relat...

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Bibliographic Details
Main Authors: Florent Colomb, Leila B. Giron, Leticia Kuri-Cervantes, Opeyemi S. Adeniji, Tongcui Ma, Harsh Dweep, Emilie Battivelli, Eric Verdin, Clovis S. Palmer, Hiroaki Tateno, Andrew V. Kossenkov, Nadia R. Roan, Michael R. Betts, Mohamed Abdel-Mohsen
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
HIV persistence
HIV transcription
glycosylation
fucose
Sialyl-LewisX
T cell trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309761

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