Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites
The synergy between gelator molecules and nanostructured materials is currently a novel matter of study. The possibility to carefully design the skeleton of the molecular entity as well as the nanostructure's morphological and chemical features offers the possibility to prepare a huge variety o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00060/full |
| _version_ | 1828443660055740416 |
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| author | Mariona Dalmases Mariona Dalmases Andrea Pinto Andrea Pinto Petra Lippmann Ingo Ott Laura Rodríguez Laura Rodríguez Albert Figuerola Albert Figuerola |
| author_facet | Mariona Dalmases Mariona Dalmases Andrea Pinto Andrea Pinto Petra Lippmann Ingo Ott Laura Rodríguez Laura Rodríguez Albert Figuerola Albert Figuerola |
| author_sort | Mariona Dalmases |
| collection | DOAJ |
| description | The synergy between gelator molecules and nanostructured materials is currently a novel matter of study. The possibility to carefully design the skeleton of the molecular entity as well as the nanostructure's morphological and chemical features offers the possibility to prepare a huge variety of nanocomposites with properties potentially different than just the sum of those of the individual building blocks. Here we describe the synthesis and characterization of nanocomposites made by the unconventional combination of phosphine-Au(I)-alkynyl-based organometallic gelating molecules and plasmonic Au nanoparticles. Our results indicate that the interaction between the two moieties leads to a significant degree of aggregation in both hydrophilic and hydrophobic media, either when using DAPTA or PTA-based organometallic molecules, with the formation of a sponge-like hybrid powder upon solvent evaporation. The biological activity of the nanocomposites was assessed, suggesting the existence of a synergetic effect evidenced by the higher cytotoxicity of the hybrid systems with respect to that of any of their isolated counterparts. These results represent a preliminary proof-of-concept for the exploitation of these novel nanocomposites in the biomedical field. |
| first_indexed | 2024-12-10T21:32:18Z |
| format | Article |
| id | doaj.art-7a945179d99d423a840ef8c4434bf015 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-10T21:32:18Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-7a945179d99d423a840ef8c4434bf0152022-12-22T01:32:45ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-02-01710.3389/fchem.2019.00060428706Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic NanocompositesMariona Dalmases0Mariona Dalmases1Andrea Pinto2Andrea Pinto3Petra Lippmann4Ingo Ott5Laura Rodríguez6Laura Rodríguez7Albert Figuerola8Albert Figuerola9Departament de Química Inorgànica i Orgànica, Secció de Química Inorgànica, Universitat de Barcelona, Barcelona, SpainInstitut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, Barcelona, SpainDepartament de Química Inorgànica i Orgànica, Secció de Química Inorgànica, Universitat de Barcelona, Barcelona, SpainInstitut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, Barcelona, SpainInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig, GermanyInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig, GermanyDepartament de Química Inorgànica i Orgànica, Secció de Química Inorgànica, Universitat de Barcelona, Barcelona, SpainInstitut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, Barcelona, SpainDepartament de Química Inorgànica i Orgànica, Secció de Química Inorgànica, Universitat de Barcelona, Barcelona, SpainInstitut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, Barcelona, SpainThe synergy between gelator molecules and nanostructured materials is currently a novel matter of study. The possibility to carefully design the skeleton of the molecular entity as well as the nanostructure's morphological and chemical features offers the possibility to prepare a huge variety of nanocomposites with properties potentially different than just the sum of those of the individual building blocks. Here we describe the synthesis and characterization of nanocomposites made by the unconventional combination of phosphine-Au(I)-alkynyl-based organometallic gelating molecules and plasmonic Au nanoparticles. Our results indicate that the interaction between the two moieties leads to a significant degree of aggregation in both hydrophilic and hydrophobic media, either when using DAPTA or PTA-based organometallic molecules, with the formation of a sponge-like hybrid powder upon solvent evaporation. The biological activity of the nanocomposites was assessed, suggesting the existence of a synergetic effect evidenced by the higher cytotoxicity of the hybrid systems with respect to that of any of their isolated counterparts. These results represent a preliminary proof-of-concept for the exploitation of these novel nanocomposites in the biomedical field.https://www.frontiersin.org/article/10.3389/fchem.2019.00060/fullnanoparticlesgoldbiological activityorganometallichybrid |
| spellingShingle | Mariona Dalmases Mariona Dalmases Andrea Pinto Andrea Pinto Petra Lippmann Ingo Ott Laura Rodríguez Laura Rodríguez Albert Figuerola Albert Figuerola Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites Frontiers in Chemistry nanoparticles gold biological activity organometallic hybrid |
| title | Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites |
| title_full | Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites |
| title_fullStr | Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites |
| title_full_unstemmed | Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites |
| title_short | Preparation and Antitumoral Activity of Au-Based Inorganic-Organometallic Nanocomposites |
| title_sort | preparation and antitumoral activity of au based inorganic organometallic nanocomposites |
| topic | nanoparticles gold biological activity organometallic hybrid |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00060/full |
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