Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation

Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation

The aim of this study was to predict the cytochrome P450 3A (CYP3A)-mediated drug–drug interactions (DDIs) between saxagliptin and nicardipine using a physiologically based pharmacokinetic (PBPK) model. Initially, in silico and in vitro parameters were gathered from experiments or the literature to...

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Bibliographic Details
Main Authors: Jeong-Min Lee, Jin-Ha Yoon, Han-Joo Maeng, Yu Chul Kim
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceutics
Subjects:
drug–drug interaction
CYP3A4
nicardipine
saxagliptin
PBPK modeling
Online Access:https://www.mdpi.com/1999-4923/16/2/280

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