Drug-induced kidney injury in Chinese critically ill pediatric patients
Background: Drug-induced acute kidney injury (DIKI) is a common adverse drug reaction event but is less known in pediatric patients. The study explored the DIKI in Chinese pediatric patients using the Pediatric Intensive Care database (PIC).Method: We screened pediatric patients with acute kidney in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.993923/full |
| _version_ | 1811204735563202560 |
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| author | Biwen Hu Ling Ye Tong Li Zeying Feng Longjian Huang Chengjun Guo Li He Wei Tan Guoping Yang Zhiling Li Chengxian Guo |
| author_facet | Biwen Hu Ling Ye Tong Li Zeying Feng Longjian Huang Chengjun Guo Li He Wei Tan Guoping Yang Zhiling Li Chengxian Guo |
| author_sort | Biwen Hu |
| collection | DOAJ |
| description | Background: Drug-induced acute kidney injury (DIKI) is a common adverse drug reaction event but is less known in pediatric patients. The study explored the DIKI in Chinese pediatric patients using the Pediatric Intensive Care database (PIC).Method: We screened pediatric patients with acute kidney injury (AKI) using the KDIGO criteria from the PIC and then assessed the relationship between their drugs and DIKI using the Naranjo scale. For the fifteen frequently used DIKI-suspected drugs, we divided patients into drug-exposed and non-exposed groups, using the outcome of whether DIKI was presented or not. Propensity score matching (PSM) was used to control for the effects of four confounders, age, gender, length of hospital stay, and major diagnosis. Unconditional logistic regression was used to identify statistically significant differences between the two groups.Results: A total of 238 drugs were used 1,863 times by the 81 patients with DIKI during their hospital stay. After screening the Naranjo scale to identify the top 15 suspected DIKI drugs with a high frequency of use, we found that furosemide injection (p = 0.001), midazolam injection (p = 0.001), 20% albumin prepared from human plasma injection (p = 0.004), fentanyl citrate injection (p = 0.001), compound glycyrrhizin injection (p = 0.026), vancomycin hydrochloride for intravenous (p = 0.010), and milrinone lactate injection (p = 0.009) were associated with DIKI.Conclusion: In critically ill pediatric patients, DIKI is more likely to occur after using furosemide injection, midazolam injection, 20% albumin prepared from human plasma injection, fentanyl citrate injection, compound glycyrrhizin injection, vancomycin hydrochloride for intravenous, milrinone lactate injection. |
| first_indexed | 2024-04-12T03:17:42Z |
| format | Article |
| id | doaj.art-7a96489210c6485a816115af30f5c0bc |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T03:17:42Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7a96489210c6485a816115af30f5c0bc2022-12-22T03:50:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.993923993923Drug-induced kidney injury in Chinese critically ill pediatric patientsBiwen Hu0Ling Ye1Tong Li2Zeying Feng3Longjian Huang4Chengjun Guo5Li He6Wei Tan7Guoping Yang8Zhiling Li9Chengxian Guo10Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaWest Guangxi Key Laboratory for Prevention and Treatment of High-Incidence Diseases, Youjiang Medical University for Nationalities, Baise, ChinaSchool of Applied Mathematics, Guangdong University of Technology, Guangzhou, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neonatology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Pharmacy, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaCenter of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaBackground: Drug-induced acute kidney injury (DIKI) is a common adverse drug reaction event but is less known in pediatric patients. The study explored the DIKI in Chinese pediatric patients using the Pediatric Intensive Care database (PIC).Method: We screened pediatric patients with acute kidney injury (AKI) using the KDIGO criteria from the PIC and then assessed the relationship between their drugs and DIKI using the Naranjo scale. For the fifteen frequently used DIKI-suspected drugs, we divided patients into drug-exposed and non-exposed groups, using the outcome of whether DIKI was presented or not. Propensity score matching (PSM) was used to control for the effects of four confounders, age, gender, length of hospital stay, and major diagnosis. Unconditional logistic regression was used to identify statistically significant differences between the two groups.Results: A total of 238 drugs were used 1,863 times by the 81 patients with DIKI during their hospital stay. After screening the Naranjo scale to identify the top 15 suspected DIKI drugs with a high frequency of use, we found that furosemide injection (p = 0.001), midazolam injection (p = 0.001), 20% albumin prepared from human plasma injection (p = 0.004), fentanyl citrate injection (p = 0.001), compound glycyrrhizin injection (p = 0.026), vancomycin hydrochloride for intravenous (p = 0.010), and milrinone lactate injection (p = 0.009) were associated with DIKI.Conclusion: In critically ill pediatric patients, DIKI is more likely to occur after using furosemide injection, midazolam injection, 20% albumin prepared from human plasma injection, fentanyl citrate injection, compound glycyrrhizin injection, vancomycin hydrochloride for intravenous, milrinone lactate injection.https://www.frontiersin.org/articles/10.3389/fphar.2022.993923/fulldrug-induced kidney injuryacute kidney injuryrational drug userational medicationpediatrics |
| spellingShingle | Biwen Hu Ling Ye Tong Li Zeying Feng Longjian Huang Chengjun Guo Li He Wei Tan Guoping Yang Zhiling Li Chengxian Guo Drug-induced kidney injury in Chinese critically ill pediatric patients Frontiers in Pharmacology drug-induced kidney injury acute kidney injury rational drug use rational medication pediatrics |
| title | Drug-induced kidney injury in Chinese critically ill pediatric patients |
| title_full | Drug-induced kidney injury in Chinese critically ill pediatric patients |
| title_fullStr | Drug-induced kidney injury in Chinese critically ill pediatric patients |
| title_full_unstemmed | Drug-induced kidney injury in Chinese critically ill pediatric patients |
| title_short | Drug-induced kidney injury in Chinese critically ill pediatric patients |
| title_sort | drug induced kidney injury in chinese critically ill pediatric patients |
| topic | drug-induced kidney injury acute kidney injury rational drug use rational medication pediatrics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.993923/full |
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