Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months
PurposeThe purpose of this study was to evaluate the immune response to serotype 19A in children aged 12-23 months after immunization of the 19F containing 7-valent pneumococcal conjugate vaccine (PCV7).MethodsBlood samples from a total of 45 subjects (age 12-23 months) were included in the study. S...
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2011-04-01
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| Series: | Korean Journal of Pediatrics |
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| Online Access: | http://kjp.or.kr/upload/pdf/kjped-54-163.pdf |
| _version_ | 1818213012904869888 |
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| author | Hyun Ju Lee So Eun Park Kyung Hyo Kim |
| author_facet | Hyun Ju Lee So Eun Park Kyung Hyo Kim |
| author_sort | Hyun Ju Lee |
| collection | DOAJ |
| description | PurposeThe purpose of this study was to evaluate the immune response to serotype 19A in children aged 12-23 months after immunization of the 19F containing 7-valent pneumococcal conjugate vaccine (PCV7).MethodsBlood samples from a total of 45 subjects (age 12-23 months) were included in the study. Subjects were categorized according to immunization status into three groups as follows: 18 subjects with 3 primary doses and 1 booster dose of PCV7 (booster group), 21 subjects with 3 primary doses before 12 months of age (primary group), and 6 subjects with no vaccination history of PCV7 (control group). An ELISA and opsonophagocytic killing assay (OPKA) was done to evaluate the immune responses against serotypes 19F and 19A.ResultsAccording to the ELISA, all subjects had antibody titers ≥0.35 µg/mL for serotypes 19F and 19A in the booster and primary group and 83.0% and 66.7% in the control group, respectively. According to the OPKA, subjects with opsonic activity (≥20) against serotypes 19F and 19A were 100% and 61.1% of the subjects in the booster group and 66.7% and 19.0% in the primary group, respectively. No subjects in the control group had opsonic antibodies against both serotypes.ConclusionIn conclusion, in children 12-23 months age who were previously vaccinated with PCV7, a cross-reactive immune response is elicited against serotype 19A after a primary series of 3 doses in a small proportion of subjects, and this response is amplified after booster vaccination. |
| first_indexed | 2024-12-12T05:57:32Z |
| format | Article |
| id | doaj.art-7a966d5c85da45fab71ecc87920cc039 |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-12T05:57:32Z |
| publishDate | 2011-04-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-7a966d5c85da45fab71ecc87920cc0392022-12-22T00:35:32ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582011-04-0154416316810.3345/kjp.2011.54.4.1632011540405Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 monthsHyun Ju Lee0So Eun Park1Kyung Hyo Kim2Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.Center for Vaccine Evaluation and Study, Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea.Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.PurposeThe purpose of this study was to evaluate the immune response to serotype 19A in children aged 12-23 months after immunization of the 19F containing 7-valent pneumococcal conjugate vaccine (PCV7).MethodsBlood samples from a total of 45 subjects (age 12-23 months) were included in the study. Subjects were categorized according to immunization status into three groups as follows: 18 subjects with 3 primary doses and 1 booster dose of PCV7 (booster group), 21 subjects with 3 primary doses before 12 months of age (primary group), and 6 subjects with no vaccination history of PCV7 (control group). An ELISA and opsonophagocytic killing assay (OPKA) was done to evaluate the immune responses against serotypes 19F and 19A.ResultsAccording to the ELISA, all subjects had antibody titers ≥0.35 µg/mL for serotypes 19F and 19A in the booster and primary group and 83.0% and 66.7% in the control group, respectively. According to the OPKA, subjects with opsonic activity (≥20) against serotypes 19F and 19A were 100% and 61.1% of the subjects in the booster group and 66.7% and 19.0% in the primary group, respectively. No subjects in the control group had opsonic antibodies against both serotypes.ConclusionIn conclusion, in children 12-23 months age who were previously vaccinated with PCV7, a cross-reactive immune response is elicited against serotype 19A after a primary series of 3 doses in a small proportion of subjects, and this response is amplified after booster vaccination.http://kjp.or.kr/upload/pdf/kjped-54-163.pdfHeptavalent pneumococcal conjugate vaccineAntibody response |
| spellingShingle | Hyun Ju Lee So Eun Park Kyung Hyo Kim Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months Korean Journal of Pediatrics Heptavalent pneumococcal conjugate vaccine Antibody response |
| title | Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months |
| title_full | Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months |
| title_fullStr | Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months |
| title_full_unstemmed | Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months |
| title_short | Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months |
| title_sort | immune response to 19a serotype after immunization of 19f containing pneumococcal conjugate vaccine in korean children aged 12 23 months |
| topic | Heptavalent pneumococcal conjugate vaccine Antibody response |
| url | http://kjp.or.kr/upload/pdf/kjped-54-163.pdf |
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