Lupus Nephritis and Dysbiosis
Lupus nephritis (LN) is one of the most common and serious complications of systemic lupus erythematosus (SLE). The risk factors for developing LN by SLE patients are not fully understood. They are considered to be a mix of genetic and environmental variables, one of them being dysbiosis, proposed r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1165 |
| _version_ | 1797606289639997440 |
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| author | Marta Monticolo Krzysztof Mucha Bartosz Foroncewicz |
| author_facet | Marta Monticolo Krzysztof Mucha Bartosz Foroncewicz |
| author_sort | Marta Monticolo |
| collection | DOAJ |
| description | Lupus nephritis (LN) is one of the most common and serious complications of systemic lupus erythematosus (SLE). The risk factors for developing LN by SLE patients are not fully understood. They are considered to be a mix of genetic and environmental variables, one of them being dysbiosis, proposed recently to interfere with autoimmunity. As of yet, the relations between the human microbiome, its genetic determinants, individual variability and clinical consequences remain to be established. One of the major obstacles in studying them is the magnitude of confounders, such as diet, drugs, infections or antibiotics use. They also make comparison between the studies extremely complicated. We reviewed the available evidence for the interplay between microbiome, dysbiosis and mechanisms triggering the autoimmune responses and potentially contributing to LN development. One such mechanism is the stimulation of autoimmune responses by bacterial metabolites that can mimic autoantigens and cause antibody production. These mimicking microbial antigens seem to be a promising target for future interventions. |
| first_indexed | 2024-03-11T05:13:07Z |
| format | Article |
| id | doaj.art-7a96b29084b64fc6b027164beaef7ddd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:13:07Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7a96b29084b64fc6b027164beaef7ddd2023-11-17T18:27:25ZengMDPI AGBiomedicines2227-90592023-04-01114116510.3390/biomedicines11041165Lupus Nephritis and DysbiosisMarta Monticolo0Krzysztof Mucha1Bartosz Foroncewicz2Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, PolandDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, PolandDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, PolandLupus nephritis (LN) is one of the most common and serious complications of systemic lupus erythematosus (SLE). The risk factors for developing LN by SLE patients are not fully understood. They are considered to be a mix of genetic and environmental variables, one of them being dysbiosis, proposed recently to interfere with autoimmunity. As of yet, the relations between the human microbiome, its genetic determinants, individual variability and clinical consequences remain to be established. One of the major obstacles in studying them is the magnitude of confounders, such as diet, drugs, infections or antibiotics use. They also make comparison between the studies extremely complicated. We reviewed the available evidence for the interplay between microbiome, dysbiosis and mechanisms triggering the autoimmune responses and potentially contributing to LN development. One such mechanism is the stimulation of autoimmune responses by bacterial metabolites that can mimic autoantigens and cause antibody production. These mimicking microbial antigens seem to be a promising target for future interventions.https://www.mdpi.com/2227-9059/11/4/1165lupus nephritissystemic lupus erythematosusdysbiosismicrobiome |
| spellingShingle | Marta Monticolo Krzysztof Mucha Bartosz Foroncewicz Lupus Nephritis and Dysbiosis Biomedicines lupus nephritis systemic lupus erythematosus dysbiosis microbiome |
| title | Lupus Nephritis and Dysbiosis |
| title_full | Lupus Nephritis and Dysbiosis |
| title_fullStr | Lupus Nephritis and Dysbiosis |
| title_full_unstemmed | Lupus Nephritis and Dysbiosis |
| title_short | Lupus Nephritis and Dysbiosis |
| title_sort | lupus nephritis and dysbiosis |
| topic | lupus nephritis systemic lupus erythematosus dysbiosis microbiome |
| url | https://www.mdpi.com/2227-9059/11/4/1165 |
| work_keys_str_mv | AT martamonticolo lupusnephritisanddysbiosis AT krzysztofmucha lupusnephritisanddysbiosis AT bartoszforoncewicz lupusnephritisanddysbiosis |