Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses
Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive immune responses and whose phenotype and function are influenced by tissue-specific conditions. Their mechanisms of activation in type I hypersensitivity reactions have been the subject of multiple studies...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2411 |
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| author | Zyanya P. Espinosa-Riquer Deisy Segura-Villalobos Itzel G. Ramírez-Moreno Marian Jesabel Pérez Rodríguez Mónica Lamas Claudia Gonzalez-Espinosa |
| author_facet | Zyanya P. Espinosa-Riquer Deisy Segura-Villalobos Itzel G. Ramírez-Moreno Marian Jesabel Pérez Rodríguez Mónica Lamas Claudia Gonzalez-Espinosa |
| author_sort | Zyanya P. Espinosa-Riquer |
| collection | DOAJ |
| description | Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive immune responses and whose phenotype and function are influenced by tissue-specific conditions. Their mechanisms of activation in type I hypersensitivity reactions have been the subject of multiple studies, but the signaling pathways behind their activation by innate immunity stimuli are not so well described. Here, we review the recent evidence regarding the main molecular elements and signaling pathways connecting the innate immune receptors and hypoxic microenvironment to cytokine synthesis and the secretion of soluble or exosome-contained mediators in this cell type. When known, the positive and negative control mechanisms of those pathways are presented, together with their possible implications for the understanding of mast cell-driven chronic inflammation. Finally, we discuss the relevance of the knowledge about signaling in this cell type in the recognition of MCs as central elements on innate immunity, whose remarkable plasticity converts them in sensors of micro-environmental discontinuities and controllers of tissue homeostasis. |
| first_indexed | 2024-03-10T15:07:05Z |
| format | Article |
| id | doaj.art-7a96b3301c3c48608fc7f3210e966aba |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:07:05Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7a96b3301c3c48608fc7f3210e966aba2023-11-20T19:42:43ZengMDPI AGCells2073-44092020-11-01911241110.3390/cells9112411Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific ResponsesZyanya P. Espinosa-Riquer0Deisy Segura-Villalobos1Itzel G. Ramírez-Moreno2Marian Jesabel Pérez Rodríguez3Mónica Lamas4Claudia Gonzalez-Espinosa5Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Mexico City 14330, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Mexico City 14330, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Mexico City 14330, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Mexico City 14330, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Mexico City 14330, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Mexico City 14330, MexicoMast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive immune responses and whose phenotype and function are influenced by tissue-specific conditions. Their mechanisms of activation in type I hypersensitivity reactions have been the subject of multiple studies, but the signaling pathways behind their activation by innate immunity stimuli are not so well described. Here, we review the recent evidence regarding the main molecular elements and signaling pathways connecting the innate immune receptors and hypoxic microenvironment to cytokine synthesis and the secretion of soluble or exosome-contained mediators in this cell type. When known, the positive and negative control mechanisms of those pathways are presented, together with their possible implications for the understanding of mast cell-driven chronic inflammation. Finally, we discuss the relevance of the knowledge about signaling in this cell type in the recognition of MCs as central elements on innate immunity, whose remarkable plasticity converts them in sensors of micro-environmental discontinuities and controllers of tissue homeostasis.https://www.mdpi.com/2073-4409/9/11/2411mast cellssignal transductioninnate immunity |
| spellingShingle | Zyanya P. Espinosa-Riquer Deisy Segura-Villalobos Itzel G. Ramírez-Moreno Marian Jesabel Pérez Rodríguez Mónica Lamas Claudia Gonzalez-Espinosa Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses Cells mast cells signal transduction innate immunity |
| title | Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses |
| title_full | Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses |
| title_fullStr | Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses |
| title_full_unstemmed | Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses |
| title_short | Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses |
| title_sort | signal transduction pathways activated by innate immunity in mast cells translating sensing of changes into specific responses |
| topic | mast cells signal transduction innate immunity |
| url | https://www.mdpi.com/2073-4409/9/11/2411 |
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