Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI
Magnetic resonance imaging (MRI) of the breast has been increasingly used for the detailed evaluation of breast lesions. Diffusion-weighted imaging (DWI) gives additional information for the lesions based on tissue cellularity. The aim of our study was to evaluate the possibilities of DWI, apparent...
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MDPI AG
2022-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/2/332 |
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| author | Silvia Tsvetkova Katya Doykova Anna Vasilska Katya Sapunarova Daniel Doykov Vladimir Andonov Petar Uchikov |
| author_facet | Silvia Tsvetkova Katya Doykova Anna Vasilska Katya Sapunarova Daniel Doykov Vladimir Andonov Petar Uchikov |
| author_sort | Silvia Tsvetkova |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) of the breast has been increasingly used for the detailed evaluation of breast lesions. Diffusion-weighted imaging (DWI) gives additional information for the lesions based on tissue cellularity. The aim of our study was to evaluate the possibilities of DWI, apparent diffusion coefficient (ADC) value and ADC ratio (the ratio between the ADC of the lesion and the ADC of normal glandular tissue) to differentiate benign from malignant breast lesions. Materials and methods: Eighty-seven patients with solid breast lesions (52 malignant and 35 benign) were examined on a 1.5 T MR scanner before histopathological evaluation. ADC values and ADC ratios were calculated. Results: The ADC values in the group with malignant tumors were significantly lower (mean 0.88 ± 0.15 × 10<sup>−3</sup> mm<sup>2</sup>/s) in comparison with the group with benign lesions (mean 1.52 ± 0.23 × 10<sup>−3</sup> mm<sup>2</sup>/s). A significantly lower ADC ratio was observed in the patients with malignant tumors (mean 0.66 ± 0.13) versus the patients with benign lesions (mean 1.12 ± 0.23). The cut-off point of the ADC value for differentiating malignant from benign breast tumors was 1.11 × 10<sup>−3</sup> mm<sup>2</sup>/s with a sensitivity of 94.23%, specificity of 94.29%, and diagnostic accuracy of 98%, and an ADC ratio of ≤0.87 with a sensitivity of 94.23%, specificity of 91.43%, and a diagnostic accuracy of 95%. Conclusion: According to the results from our study DWI, ADC values and ADC ratio proved to be valuable additional techniques with high sensitivity and specificity for distinguishing benign from malignant breast lesions. |
| first_indexed | 2024-03-09T22:12:24Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T22:12:24Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-7a977e57bc904881bb31b64fe32291c02023-11-23T19:30:18ZengMDPI AGDiagnostics2075-44182022-01-0112233210.3390/diagnostics12020332Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRISilvia Tsvetkova0Katya Doykova1Anna Vasilska2Katya Sapunarova3Daniel Doykov4Vladimir Andonov5Petar Uchikov6Department of Diagnostic Imaging, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaDepartment of Diagnostic Imaging, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaDepartment of Diagnostic Imaging, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaFirst Department of Internal Diseases, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaSecond Department of Internal Diseases, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaSecond Department of Internal Diseases, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaDepartment of Special Surgery, Medical University Plovdiv, 15-A Vasil Aprilov Blvd, 4002 Plovdiv, BulgariaMagnetic resonance imaging (MRI) of the breast has been increasingly used for the detailed evaluation of breast lesions. Diffusion-weighted imaging (DWI) gives additional information for the lesions based on tissue cellularity. The aim of our study was to evaluate the possibilities of DWI, apparent diffusion coefficient (ADC) value and ADC ratio (the ratio between the ADC of the lesion and the ADC of normal glandular tissue) to differentiate benign from malignant breast lesions. Materials and methods: Eighty-seven patients with solid breast lesions (52 malignant and 35 benign) were examined on a 1.5 T MR scanner before histopathological evaluation. ADC values and ADC ratios were calculated. Results: The ADC values in the group with malignant tumors were significantly lower (mean 0.88 ± 0.15 × 10<sup>−3</sup> mm<sup>2</sup>/s) in comparison with the group with benign lesions (mean 1.52 ± 0.23 × 10<sup>−3</sup> mm<sup>2</sup>/s). A significantly lower ADC ratio was observed in the patients with malignant tumors (mean 0.66 ± 0.13) versus the patients with benign lesions (mean 1.12 ± 0.23). The cut-off point of the ADC value for differentiating malignant from benign breast tumors was 1.11 × 10<sup>−3</sup> mm<sup>2</sup>/s with a sensitivity of 94.23%, specificity of 94.29%, and diagnostic accuracy of 98%, and an ADC ratio of ≤0.87 with a sensitivity of 94.23%, specificity of 91.43%, and a diagnostic accuracy of 95%. Conclusion: According to the results from our study DWI, ADC values and ADC ratio proved to be valuable additional techniques with high sensitivity and specificity for distinguishing benign from malignant breast lesions.https://www.mdpi.com/2075-4418/12/2/332breast MRIDWIADC valueADC ratiobreast lesions |
| spellingShingle | Silvia Tsvetkova Katya Doykova Anna Vasilska Katya Sapunarova Daniel Doykov Vladimir Andonov Petar Uchikov Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI Diagnostics breast MRI DWI ADC value ADC ratio breast lesions |
| title | Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI |
| title_full | Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI |
| title_fullStr | Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI |
| title_full_unstemmed | Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI |
| title_short | Differentiation of Benign and Malignant Breast Lesions Using ADC Values and ADC Ratio in Breast MRI |
| title_sort | differentiation of benign and malignant breast lesions using adc values and adc ratio in breast mri |
| topic | breast MRI DWI ADC value ADC ratio breast lesions |
| url | https://www.mdpi.com/2075-4418/12/2/332 |
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