Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis
Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/3929 |
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| author | Marta Rapado-Castro Mara Villar-Arenzana Joost Janssen David Fraguas Igor Bombin Josefina Castro-Fornieles Maria Mayoral Ana González-Pinto Elena de la Serna Mara Parellada Dolores Moreno Beatriz Paya Montserrat Graell Inmaculada Baeza Christos Pantelis Celso Arango |
| author_facet | Marta Rapado-Castro Mara Villar-Arenzana Joost Janssen David Fraguas Igor Bombin Josefina Castro-Fornieles Maria Mayoral Ana González-Pinto Elena de la Serna Mara Parellada Dolores Moreno Beatriz Paya Montserrat Graell Inmaculada Baeza Christos Pantelis Celso Arango |
| author_sort | Marta Rapado-Castro |
| collection | DOAJ |
| description | Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096, <i>p</i> = 0.008); right (B = 0.089, <i>p</i> = 0.015); parietal left (B = 0.119, <i>p</i> = 0.007), right (B = 0.125, <i>p</i> = 0.015)) as a function of age. A particular decrease in frontal left GM volume best predicted a significant amount (22.28%) of the variance of decreased working memory performance over time, accounting for variance in age (14.9%). No such association was found in controls. Our results suggest that during adolescence, EOP individuals seem to follow an abnormal neurodevelopmental trajectory, in which fronto-parietal GM volume reduction is associated with the differential age-related working memory dysfunction in this group. |
| first_indexed | 2024-03-10T08:08:51Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:08:51Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7a980c198e7f42a995df633921d14fc42023-11-22T10:49:31ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011017392910.3390/jcm10173929Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of PsychosisMarta Rapado-Castro0Mara Villar-Arenzana1Joost Janssen2David Fraguas3Igor Bombin4Josefina Castro-Fornieles5Maria Mayoral6Ana González-Pinto7Elena de la Serna8Mara Parellada9Dolores Moreno10Beatriz Paya11Montserrat Graell12Inmaculada Baeza13Christos Pantelis14Celso Arango15Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28040 Madrid, SpainDepartment of Psychiatry, School of Medicine, Universidad Complutense, 28040 Madrid, SpainDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28040 Madrid, SpainInstitute of Psychiatry and Mental Health, Hospital Clínico San Carlos, IdISSC, CIBERSAM, School of Medicine, Universidad Complutense, 28040 Madrid, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 33011 Oviedo, SpainChild Psychiatry and Psychology Department, 2017SGR881, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS (Institut d’Investigacions Biomèdiques August Pi Sunyer), CIBERSAM (Centro deInvestigación Biomédica en Red de Salud Mental), Department of Medicine University of Barcelona, 28036 Barcelona, SpainDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28040 Madrid, SpainHospital Universitario de Álava, BIOARABA, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Kronikgune, EHU-UPV, 01009 Vitoria, SpainChild Psychiatry and Psychology Department, 2017SGR881, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS (Institut d’Investigacions Biomèdiques August Pi Sunyer), CIBERSAM (Centro deInvestigación Biomédica en Red de Salud Mental), Department of Medicine University of Barcelona, 28036 Barcelona, SpainDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28040 Madrid, SpainDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28040 Madrid, SpainChild Psychiatry Unit, Hospital Universitario Marqués de Valdecilla, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, 39008 Santander, SpainPsychiatry and Psychology Department, Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, 28009 Madrid, SpainChild Psychiatry and Psychology Department, 2017SGR881, Neurosciences Institute, Hospital Clinic de Barcelona, IDIBAPS (Institut d’Investigacions Biomèdiques August Pi Sunyer), CIBERSAM (Centro deInvestigación Biomédica en Red de Salud Mental), Department of Medicine University of Barcelona, 28036 Barcelona, SpainMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, VIC 3053, AustraliaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, 28040 Madrid, SpainCognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096, <i>p</i> = 0.008); right (B = 0.089, <i>p</i> = 0.015); parietal left (B = 0.119, <i>p</i> = 0.007), right (B = 0.125, <i>p</i> = 0.015)) as a function of age. A particular decrease in frontal left GM volume best predicted a significant amount (22.28%) of the variance of decreased working memory performance over time, accounting for variance in age (14.9%). No such association was found in controls. Our results suggest that during adolescence, EOP individuals seem to follow an abnormal neurodevelopmental trajectory, in which fronto-parietal GM volume reduction is associated with the differential age-related working memory dysfunction in this group.https://www.mdpi.com/2077-0383/10/17/3929working memoryattentionexecutive functionearly onset psychosisbrain volumeadolescence |
| spellingShingle | Marta Rapado-Castro Mara Villar-Arenzana Joost Janssen David Fraguas Igor Bombin Josefina Castro-Fornieles Maria Mayoral Ana González-Pinto Elena de la Serna Mara Parellada Dolores Moreno Beatriz Paya Montserrat Graell Inmaculada Baeza Christos Pantelis Celso Arango Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis Journal of Clinical Medicine working memory attention executive function early onset psychosis brain volume adolescence |
| title | Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis |
| title_full | Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis |
| title_fullStr | Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis |
| title_full_unstemmed | Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis |
| title_short | Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis |
| title_sort | fronto parietal gray matter volume loss is associated with decreased working memory performance in adolescents with a first episode of psychosis |
| topic | working memory attention executive function early onset psychosis brain volume adolescence |
| url | https://www.mdpi.com/2077-0383/10/17/3929 |
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