New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1

New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1

Abstract Background Microvesicles (MVs) derived from human bone marrow mesenchymal stem cell (MSC) were demonstrated to restore lung protein permeability and attenuate acute lung injury. In our previous study, we found that MSC MV increased sphingosine-1-phosphate (S1P) kinase1 mRNA levels in injure...

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Bibliographic Details
Main Authors:	Lifang Ye, Jieqiong Song, Yijun Zheng, Ming Zhong, Jun Liu, Duming Zhu, Shuling Hu
Format:	Article
Language:	English
Published:	BMC 2022-10-01
Series:	Stem Cell Research & Therapy
Subjects:	Mesenchymal stem cell Microvesicles Human lung microvascular endothelial cell Pulmonary endothelial permeability Sphingosine-1-phosphate
Online Access:	https://doi.org/10.1186/s13287-022-03177-4

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