Hydrogels Based on Poly(aspartic acid): Synthesis and Applications
This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a synthetic acidic polypeptide that has drawn a great deal of attention in diverse applications due particularly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00755/full |
| _version_ | 1818272528337993728 |
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| author | Hossein Adelnia Hossein Adelnia Idriss Blakey Peter J. Little Peter J. Little Hang T. Ta Hang T. Ta |
| author_facet | Hossein Adelnia Hossein Adelnia Idriss Blakey Peter J. Little Peter J. Little Hang T. Ta Hang T. Ta |
| author_sort | Hossein Adelnia |
| collection | DOAJ |
| description | This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a synthetic acidic polypeptide that has drawn a great deal of attention in diverse applications due particularly to its biocompatibility and biodegradability. Facile modification of its precursor, poly(succinimide) (PSI), by primary amines has opened a wide window for the design of state-of-the-art hydrogels. Apart from pH-sensitivity, PASP hydrogels can be modified with suitable species in order to respond to the other desired stimuli such as temperature and reducing/oxidizing media as well. Strategies for fabrication of nanostructured PASP-based hydrogels in the form of particle and fiber are also discussed. Different cross-linking agents for PSI/PASP such as diamines, dopamine, cysteamine, and aminosilanes are also introduced. Finally, applications of PASP-based hydrogels in diverse areas particularly in biomedical are reviewed. |
| first_indexed | 2024-12-12T21:43:30Z |
| format | Article |
| id | doaj.art-7a9a6d015a504dd9be1760a1da27181e |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-12T21:43:30Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-7a9a6d015a504dd9be1760a1da27181e2022-12-22T00:10:59ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-11-01710.3389/fchem.2019.00755492778Hydrogels Based on Poly(aspartic acid): Synthesis and ApplicationsHossein Adelnia0Hossein Adelnia1Idriss Blakey2Peter J. Little3Peter J. Little4Hang T. Ta5Hang T. Ta6Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, AustraliaSchool of Pharmacy, University of Queensland, Woolloongabba, QLD, AustraliaAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, AustraliaSchool of Pharmacy, University of Queensland, Woolloongabba, QLD, AustraliaDepartment of Pharmacy, Xinhua College of Sun Yat-sen University, Guangzhou, ChinaAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, AustraliaSchool of Pharmacy, University of Queensland, Woolloongabba, QLD, AustraliaThis review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a synthetic acidic polypeptide that has drawn a great deal of attention in diverse applications due particularly to its biocompatibility and biodegradability. Facile modification of its precursor, poly(succinimide) (PSI), by primary amines has opened a wide window for the design of state-of-the-art hydrogels. Apart from pH-sensitivity, PASP hydrogels can be modified with suitable species in order to respond to the other desired stimuli such as temperature and reducing/oxidizing media as well. Strategies for fabrication of nanostructured PASP-based hydrogels in the form of particle and fiber are also discussed. Different cross-linking agents for PSI/PASP such as diamines, dopamine, cysteamine, and aminosilanes are also introduced. Finally, applications of PASP-based hydrogels in diverse areas particularly in biomedical are reviewed.https://www.frontiersin.org/article/10.3389/fchem.2019.00755/fullhydrogelspoly(aspartic acid)poly(succinimide)crosslinkingnanoparticlesinterpenetrating polymer networks (IPNs) |
| spellingShingle | Hossein Adelnia Hossein Adelnia Idriss Blakey Peter J. Little Peter J. Little Hang T. Ta Hang T. Ta Hydrogels Based on Poly(aspartic acid): Synthesis and Applications Frontiers in Chemistry hydrogels poly(aspartic acid) poly(succinimide) crosslinking nanoparticles interpenetrating polymer networks (IPNs) |
| title | Hydrogels Based on Poly(aspartic acid): Synthesis and Applications |
| title_full | Hydrogels Based on Poly(aspartic acid): Synthesis and Applications |
| title_fullStr | Hydrogels Based on Poly(aspartic acid): Synthesis and Applications |
| title_full_unstemmed | Hydrogels Based on Poly(aspartic acid): Synthesis and Applications |
| title_short | Hydrogels Based on Poly(aspartic acid): Synthesis and Applications |
| title_sort | hydrogels based on poly aspartic acid synthesis and applications |
| topic | hydrogels poly(aspartic acid) poly(succinimide) crosslinking nanoparticles interpenetrating polymer networks (IPNs) |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00755/full |
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