General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report
Abstract Background Systemic anesthetic management of patients with mitochondrial disease requires careful preoperative preparation to administer adequate anesthesia and address potential disease-related complications. The appropriate general anesthetic agents to use in these patients remain controv...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-06-01
|
| Series: | JA Clinical Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40981-021-00454-8 |
| _version_ | 1818849613656883200 |
|---|---|
| author | Yuji Suzuki Matsuyuki Doi Yoshiki Nakajima |
| author_facet | Yuji Suzuki Matsuyuki Doi Yoshiki Nakajima |
| author_sort | Yuji Suzuki |
| collection | DOAJ |
| description | Abstract Background Systemic anesthetic management of patients with mitochondrial disease requires careful preoperative preparation to administer adequate anesthesia and address potential disease-related complications. The appropriate general anesthetic agents to use in these patients remain controversial. Case presentation A 54-year-old woman (height, 145 cm; weight, 43 kg) diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes underwent elective cochlear implantation. Infusions of intravenous remimazolam and remifentanil guided by patient state index monitoring were used for anesthesia induction and maintenance. Neither lactic acidosis nor prolonged muscle relaxation occurred in the perioperative period. At the end of surgery, flumazenil was administered to antagonize sedation, which rapidly resulted in consciousness. Conclusions Remimazolam administration and reversal with flumazenil were successfully used for general anesthesia in a patient with mitochondrial disease. |
| first_indexed | 2024-12-19T06:36:01Z |
| format | Article |
| id | doaj.art-7a9c7d29c4fb42c5b91a8d7ec86e38dc |
| institution | Directory Open Access Journal |
| issn | 2363-9024 |
| language | English |
| last_indexed | 2024-12-19T06:36:01Z |
| publishDate | 2021-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | JA Clinical Reports |
| spelling | doaj.art-7a9c7d29c4fb42c5b91a8d7ec86e38dc2022-12-21T20:32:14ZengSpringerOpenJA Clinical Reports2363-90242021-06-01711310.1186/s40981-021-00454-8General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case reportYuji Suzuki0Matsuyuki Doi1Yoshiki Nakajima2Department of Anesthesiology and Intensive Care Medicine, Hamamatsu University School of MedicineDepartment of Anesthesiology and Intensive Care Medicine, Hamamatsu University School of MedicineDepartment of Anesthesiology and Intensive Care Medicine, Hamamatsu University School of MedicineAbstract Background Systemic anesthetic management of patients with mitochondrial disease requires careful preoperative preparation to administer adequate anesthesia and address potential disease-related complications. The appropriate general anesthetic agents to use in these patients remain controversial. Case presentation A 54-year-old woman (height, 145 cm; weight, 43 kg) diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes underwent elective cochlear implantation. Infusions of intravenous remimazolam and remifentanil guided by patient state index monitoring were used for anesthesia induction and maintenance. Neither lactic acidosis nor prolonged muscle relaxation occurred in the perioperative period. At the end of surgery, flumazenil was administered to antagonize sedation, which rapidly resulted in consciousness. Conclusions Remimazolam administration and reversal with flumazenil were successfully used for general anesthesia in a patient with mitochondrial disease.https://doi.org/10.1186/s40981-021-00454-8RemimazolamMitochondrial encephalomyopathy with lactic acidosis and stroke-like episodesMitochondrial myopathyFlumazenil |
| spellingShingle | Yuji Suzuki Matsuyuki Doi Yoshiki Nakajima General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report JA Clinical Reports Remimazolam Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes Mitochondrial myopathy Flumazenil |
| title | General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report |
| title_full | General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report |
| title_fullStr | General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report |
| title_full_unstemmed | General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report |
| title_short | General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report |
| title_sort | general anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy a case report |
| topic | Remimazolam Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes Mitochondrial myopathy Flumazenil |
| url | https://doi.org/10.1186/s40981-021-00454-8 |
| work_keys_str_mv | AT yujisuzuki generalanesthesiawithremimazolaminapatientwithmitochondrialencephalomyopathyacasereport AT matsuyukidoi generalanesthesiawithremimazolaminapatientwithmitochondrialencephalomyopathyacasereport AT yoshikinakajima generalanesthesiawithremimazolaminapatientwithmitochondrialencephalomyopathyacasereport |