A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors
The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnh...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2015-01-01
|
| Series: | MATEC Web of Conferences |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/matecconf/20152502002 |
| _version_ | 1819282620891004928 |
|---|---|
| author | Liu Sijie Zhang Baohua Jia Pengfei Niu Nan He Jingyu Shi Lanxiang |
| author_facet | Liu Sijie Zhang Baohua Jia Pengfei Niu Nan He Jingyu Shi Lanxiang |
| author_sort | Liu Sijie |
| collection | DOAJ |
| description | The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4) lonic liquid as the catalyst and solvent. The study of AChE inhibitory activity was carried out through using the Ellman colorimetric assay. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones had been successfully synthesized by green catalyst. Most of the target compounds exhibited more than 50% inhibition at 10μM. |
| first_indexed | 2024-12-24T01:18:29Z |
| format | Article |
| id | doaj.art-7a9cc22e1bd548d2a96074a3bc7d0251 |
| institution | Directory Open Access Journal |
| issn | 2261-236X |
| language | English |
| last_indexed | 2024-12-24T01:18:29Z |
| publishDate | 2015-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | MATEC Web of Conferences |
| spelling | doaj.art-7a9cc22e1bd548d2a96074a3bc7d02512022-12-21T17:22:43ZengEDP SciencesMATEC Web of Conferences2261-236X2015-01-01250200210.1051/matecconf/20152502002matecconf_emme2015_02002A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE InhibitorsLiu Sijie0Zhang Baohua1Jia Pengfei2Niu Nan3He Jingyu4Shi Lanxiang5College of Chemical Engineering, Shijiazhuang UniversityCollege of Chemical Engineering, Shijiazhuang UniversityCollege of Chemical Engineering, Shijiazhuang UniversityCollege of Chemical Engineering, Shijiazhuang UniversityCollege of Chemical Engineering, Shijiazhuang UniversityCollege of Chemical Engineering, Shijiazhuang UniversityThe authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4) lonic liquid as the catalyst and solvent. The study of AChE inhibitory activity was carried out through using the Ellman colorimetric assay. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones had been successfully synthesized by green catalyst. Most of the target compounds exhibited more than 50% inhibition at 10μM.http://dx.doi.org/10.1051/matecconf/201525020027H-thiazolo[3,2-b][1,2,4]triazin-7-oneslonic liquidAChE inhibitorsynthesize |
| spellingShingle | Liu Sijie Zhang Baohua Jia Pengfei Niu Nan He Jingyu Shi Lanxiang A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors MATEC Web of Conferences 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones lonic liquid AChE inhibitor synthesize |
| title | A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors |
| title_full | A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors |
| title_fullStr | A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors |
| title_full_unstemmed | A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors |
| title_short | A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2, 4]-triazin-7-one Derivatives as AChE Inhibitors |
| title_sort | green method for synthesis of 7h thiazolo 3 2 b 1 2 4 triazin 7 one derivatives as ache inhibitors |
| topic | 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones lonic liquid AChE inhibitor synthesize |
| url | http://dx.doi.org/10.1051/matecconf/20152502002 |
| work_keys_str_mv | AT liusijie agreenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT zhangbaohua agreenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT jiapengfei agreenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT niunan agreenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT hejingyu agreenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT shilanxiang agreenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT liusijie greenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT zhangbaohua greenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT jiapengfei greenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT niunan greenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT hejingyu greenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors AT shilanxiang greenmethodforsynthesisof7hthiazolo32b124triazin7onederivativesasacheinhibitors |