Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression.
Changes in synaptic efficacies need to be long-lasting in order to serve as a substrate for memory. Experimentally, synaptic plasticity exhibits phases covering the induction of long-term potentiation and depression (LTP/LTD) during the early phase of synaptic plasticity, the setting of synaptic tag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-12-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC2596310?pdf=render |
| _version_ | 1811338084933959680 |
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| author | Claudia Clopath Lorric Ziegler Eleni Vasilaki Lars Büsing Wulfram Gerstner |
| author_facet | Claudia Clopath Lorric Ziegler Eleni Vasilaki Lars Büsing Wulfram Gerstner |
| author_sort | Claudia Clopath |
| collection | DOAJ |
| description | Changes in synaptic efficacies need to be long-lasting in order to serve as a substrate for memory. Experimentally, synaptic plasticity exhibits phases covering the induction of long-term potentiation and depression (LTP/LTD) during the early phase of synaptic plasticity, the setting of synaptic tags, a trigger process for protein synthesis, and a slow transition leading to synaptic consolidation during the late phase of synaptic plasticity. We present a mathematical model that describes these different phases of synaptic plasticity. The model explains a large body of experimental data on synaptic tagging and capture, cross-tagging, and the late phases of LTP and LTD. Moreover, the model accounts for the dependence of LTP and LTD induction on voltage and presynaptic stimulation frequency. The stabilization of potentiated synapses during the transition from early to late LTP occurs by protein synthesis dynamics that are shared by groups of synapses. The functional consequence of this shared process is that previously stabilized patterns of strong or weak synapses onto the same postsynaptic neuron are well protected against later changes induced by LTP/LTD protocols at individual synapses. |
| first_indexed | 2024-04-13T18:05:30Z |
| format | Article |
| id | doaj.art-7a9cf5ca6fb245e4bd666bf8e73d5d21 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-13T18:05:30Z |
| publishDate | 2008-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-7a9cf5ca6fb245e4bd666bf8e73d5d212022-12-22T02:36:05ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582008-12-01412e100024810.1371/journal.pcbi.1000248Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression.Claudia ClopathLorric ZieglerEleni VasilakiLars BüsingWulfram GerstnerChanges in synaptic efficacies need to be long-lasting in order to serve as a substrate for memory. Experimentally, synaptic plasticity exhibits phases covering the induction of long-term potentiation and depression (LTP/LTD) during the early phase of synaptic plasticity, the setting of synaptic tags, a trigger process for protein synthesis, and a slow transition leading to synaptic consolidation during the late phase of synaptic plasticity. We present a mathematical model that describes these different phases of synaptic plasticity. The model explains a large body of experimental data on synaptic tagging and capture, cross-tagging, and the late phases of LTP and LTD. Moreover, the model accounts for the dependence of LTP and LTD induction on voltage and presynaptic stimulation frequency. The stabilization of potentiated synapses during the transition from early to late LTP occurs by protein synthesis dynamics that are shared by groups of synapses. The functional consequence of this shared process is that previously stabilized patterns of strong or weak synapses onto the same postsynaptic neuron are well protected against later changes induced by LTP/LTD protocols at individual synapses.http://europepmc.org/articles/PMC2596310?pdf=render |
| spellingShingle | Claudia Clopath Lorric Ziegler Eleni Vasilaki Lars Büsing Wulfram Gerstner Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. PLoS Computational Biology |
| title | Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. |
| title_full | Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. |
| title_fullStr | Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. |
| title_full_unstemmed | Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. |
| title_short | Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. |
| title_sort | tag trigger consolidation a model of early and late long term potentiation and depression |
| url | http://europepmc.org/articles/PMC2596310?pdf=render |
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