CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS
The study included 108 patients with B-cell lymphoma which had complication with invasive aspergillosis, 57 patients with Hodgkin lymphoma (HL) and 51 patients with non-Hodgkin lymphoma (NHL). All patients in both groups received chemotherapy before the development of invasive aspergillosis, 73% of...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2017-06-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/1899 |
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| author | Y. A. CHUDINOVSKIKH T. Y. SEMIGLAZOVA N. N. KLIMKO A. A. BARCHUK O. V. SHADRIVOVA E. V. FROLOVA T. S. BOGOMOLOVA S. M. IGNATIEVA S. M. ALEXEEV I. S. ZYUZGIN L. V. FILATOVA V. V. SEMIGLAZOV E. V. KHARCHENKO A. B. KOSICHKINA M. S. MOTALKINA U. B. KHADONOV Y. A. OLEYNIK A. A. ZVERKOVA I. V. OSHMATOVA A. Y. SUBORA S. A. SHALAEV P. S. SHILO S. M. ALEXEEV |
| author_facet | Y. A. CHUDINOVSKIKH T. Y. SEMIGLAZOVA N. N. KLIMKO A. A. BARCHUK O. V. SHADRIVOVA E. V. FROLOVA T. S. BOGOMOLOVA S. M. IGNATIEVA S. M. ALEXEEV I. S. ZYUZGIN L. V. FILATOVA V. V. SEMIGLAZOV E. V. KHARCHENKO A. B. KOSICHKINA M. S. MOTALKINA U. B. KHADONOV Y. A. OLEYNIK A. A. ZVERKOVA I. V. OSHMATOVA A. Y. SUBORA S. A. SHALAEV P. S. SHILO S. M. ALEXEEV |
| author_sort | Y. A. CHUDINOVSKIKH |
| collection | DOAJ |
| description | The study included 108 patients with B-cell lymphoma which had complication with invasive aspergillosis, 57 patients with Hodgkin lymphoma (HL) and 51 patients with non-Hodgkin lymphoma (NHL). All patients in both groups received chemotherapy before the development of invasive aspergillosis, 73% of patients with HL and 67% patients with NHL received chemotherapy for induction and consolidation of remission. The main predictive factors for IA in patients with HL and NHL were: prolonged lymphocytopenia (70% vs 48%), agranulocytosis (64% vs 71%), use of glucocorticosteroids as part of treatment protocol (61% vs 85%), presence of B – symptoms (63% vs 48%), respectively. In most cases nosocomial invasive aspergillosis was diagnosed in both groups: 65% vs 83% respectively. We identified etiological agents in Hodgkin and non-Hodgkin lymphoma patients: A. fumigatus (50% vs 39%), A. niger (43% vs 33%) and A. flavus (7% vs 8%). The lungs were involved in 100% cases, in group with NHL patients 6% had combined lesions in lungs and other organs and different types of tissues. Clinical manifestation of IA was nonspecific in both groups: fever – 83% vs 76%, cough – 75% vs 59%, respiratory insufficiency – 50% vs 40%, respectively. CT-signs of IA were also nonspecific in both groups: infiltrative (75% vs 66%), focal changes (61% vs 63%), and «ground-glass opacity» (28% vs 31%), respectively. In most cases patients were treated with voriconazole in both patients (88% vs 98%). Overall 12-weeks survival in patients with Hodgkin lymphoma and invasive aspergillosis was 84%, in patients with non-Hodgkin lymphoma and invasive aspergillosis – 81%. |
| first_indexed | 2024-04-09T16:29:42Z |
| format | Article |
| id | doaj.art-7a9d96e5007f4cf1b099f32abda769c3 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:29:42Z |
| publishDate | 2017-06-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-7a9d96e5007f4cf1b099f32abda769c32023-04-23T06:57:10ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902017-06-010614014510.21518/2079-701X-2017-6-140-1451876CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTSY. A. CHUDINOVSKIKH0T. Y. SEMIGLAZOVA1N. N. KLIMKO2A. A. BARCHUK3O. V. SHADRIVOVA4E. V. FROLOVA5T. S. BOGOMOLOVA6S. M. IGNATIEVA7S. M. ALEXEEV8I. S. ZYUZGIN9L. V. FILATOVA10V. V. SEMIGLAZOV11E. V. KHARCHENKO12A. B. KOSICHKINA13M. S. MOTALKINA14U. B. KHADONOV15Y. A. OLEYNIK16A. A. ZVERKOVA17I. V. OSHMATOVA18A. Y. SUBORA19S. A. SHALAEV20P. S. SHILO21S. M. ALEXEEV22Petrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaMechnikov North-Western State Medical University of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaMechnikov North-Western State Medical University of the Ministry of Health of RussiaMechnikov North-Western State Medical University of the Ministry of Health of RussiaMechnikov North-Western State Medical University of the Ministry of Health of RussiaMechnikov North-Western State Medical University of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of Russia Pavlov First Saint-Petersburg State Medical University of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaPetrov Scientific and Research Oncology Institute of the Ministry of Health of RussiaThe study included 108 patients with B-cell lymphoma which had complication with invasive aspergillosis, 57 patients with Hodgkin lymphoma (HL) and 51 patients with non-Hodgkin lymphoma (NHL). All patients in both groups received chemotherapy before the development of invasive aspergillosis, 73% of patients with HL and 67% patients with NHL received chemotherapy for induction and consolidation of remission. The main predictive factors for IA in patients with HL and NHL were: prolonged lymphocytopenia (70% vs 48%), agranulocytosis (64% vs 71%), use of glucocorticosteroids as part of treatment protocol (61% vs 85%), presence of B – symptoms (63% vs 48%), respectively. In most cases nosocomial invasive aspergillosis was diagnosed in both groups: 65% vs 83% respectively. We identified etiological agents in Hodgkin and non-Hodgkin lymphoma patients: A. fumigatus (50% vs 39%), A. niger (43% vs 33%) and A. flavus (7% vs 8%). The lungs were involved in 100% cases, in group with NHL patients 6% had combined lesions in lungs and other organs and different types of tissues. Clinical manifestation of IA was nonspecific in both groups: fever – 83% vs 76%, cough – 75% vs 59%, respiratory insufficiency – 50% vs 40%, respectively. CT-signs of IA were also nonspecific in both groups: infiltrative (75% vs 66%), focal changes (61% vs 63%), and «ground-glass opacity» (28% vs 31%), respectively. In most cases patients were treated with voriconazole in both patients (88% vs 98%). Overall 12-weeks survival in patients with Hodgkin lymphoma and invasive aspergillosis was 84%, in patients with non-Hodgkin lymphoma and invasive aspergillosis – 81%.https://www.med-sovet.pro/jour/article/view/1899invasive aspergillosisb-cell lymphomaaspergillus spp |
| spellingShingle | Y. A. CHUDINOVSKIKH T. Y. SEMIGLAZOVA N. N. KLIMKO A. A. BARCHUK O. V. SHADRIVOVA E. V. FROLOVA T. S. BOGOMOLOVA S. M. IGNATIEVA S. M. ALEXEEV I. S. ZYUZGIN L. V. FILATOVA V. V. SEMIGLAZOV E. V. KHARCHENKO A. B. KOSICHKINA M. S. MOTALKINA U. B. KHADONOV Y. A. OLEYNIK A. A. ZVERKOVA I. V. OSHMATOVA A. Y. SUBORA S. A. SHALAEV P. S. SHILO S. M. ALEXEEV CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS Медицинский совет invasive aspergillosis b-cell lymphoma aspergillus spp |
| title | CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS |
| title_full | CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS |
| title_fullStr | CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS |
| title_full_unstemmed | CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS |
| title_short | CLINICAL, LABORATORY AND X-RAY PECULIARITIES OF INVASIVE ASPERGILLOSIS IN B-CELLULAR LYMPHOMS PATIENTS |
| title_sort | clinical laboratory and x ray peculiarities of invasive aspergillosis in b cellular lymphoms patients |
| topic | invasive aspergillosis b-cell lymphoma aspergillus spp |
| url | https://www.med-sovet.pro/jour/article/view/1899 |
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