Methylphenidate’s Effect on Cerebral Blood Flow in Patients with Narcolepsy
We performed 99mTc-ethyl cysteinate dimer brain single-photon emission computed tomography before and after administering methyl-phenidate, for four weeks, to narcolepsy patients with cataplexy. Cerebral blood flow increased in the bilateral cingulate gyri and both thalami with methylphenidate treat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Sleep Medicine
2010-11-01
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| Series: | Sleep Medicine Research |
| Subjects: | |
| Online Access: | http://www.sleepmedres.org/upload/pdf/smr-1-1-30.pdf |
| Summary: | We performed 99mTc-ethyl cysteinate dimer brain single-photon emission computed tomography before and after administering methyl-phenidate, for four weeks, to narcolepsy patients with cataplexy. Cerebral blood flow increased in the bilateral cingulate gyri and both thalami with methylphenidate treatment as compared to pre-methylphenidate treatment. methylphenidate treatment also produced an regional cerebral blood flow increase in the bilateral nucleus accumbens, cingulate gyri, superior frontal gyri, and bilateral amygdalo-hippocampi and parahippocampal gyri as compared to pre-methylphenidate treatment. Moreover, no brain region showed a significant regional cerebral blood flow decrease after methylphenidate treatment. |
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| ISSN: | 2093-9175 2233-8853 |