Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature
Abstract Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03448-8 |
| _version_ | 1797577751619698688 |
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| author | Ana S. Iltis Grace Koster Emily Reeves Kirstin R. W. Matthews |
| author_facet | Ana S. Iltis Grace Koster Emily Reeves Kirstin R. W. Matthews |
| author_sort | Ana S. Iltis |
| collection | DOAJ |
| description | Abstract Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticated and could resemble human embryos ever more closely as research progresses. This paper reports a systematic review of the ethical, legal, regulatory, and policy questions and concerns found in the literature concerning human embryoid research published from 2016 to 2022. We identified 56 papers that use 53 distinct names or terms to refer to embryoids and four broad categories of ethical, legal, regulatory, or policy considerations in the literature: research justifications/benefits, ethical significance or moral status, permissible use, and regulatory and oversight challenges. Analyzing the full range of issues is a critical step toward fostering more robust ethical, legal, and social implications research in this emerging area and toward developing appropriate oversight. |
| first_indexed | 2024-03-10T22:12:25Z |
| format | Article |
| id | doaj.art-7aa02e17b6b94eb3a348eca2c1d468a9 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-10T22:12:25Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-7aa02e17b6b94eb3a348eca2c1d468a92023-11-19T12:33:22ZengBMCStem Cell Research & Therapy1757-65122023-08-0114111510.1186/s13287-023-03448-8Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literatureAna S. Iltis0Grace Koster1Emily Reeves2Kirstin R. W. Matthews3Center for Bioethics, Health and Society and Department of Philosophy, Wake Forest UniversityCenter for Bioethics, Health and Society and Department of Philosophy, Wake Forest UniversityCenter for Bioethics, Health and Society and Department of Philosophy, Wake Forest UniversityBaker Institute for Public Policy, Rice UniversityAbstract Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticated and could resemble human embryos ever more closely as research progresses. This paper reports a systematic review of the ethical, legal, regulatory, and policy questions and concerns found in the literature concerning human embryoid research published from 2016 to 2022. We identified 56 papers that use 53 distinct names or terms to refer to embryoids and four broad categories of ethical, legal, regulatory, or policy considerations in the literature: research justifications/benefits, ethical significance or moral status, permissible use, and regulatory and oversight challenges. Analyzing the full range of issues is a critical step toward fostering more robust ethical, legal, and social implications research in this emerging area and toward developing appropriate oversight.https://doi.org/10.1186/s13287-023-03448-8EmbryoidsEmbryosEthicsPluripotent stem cellsSocial implicationsSynthetic embryos |
| spellingShingle | Ana S. Iltis Grace Koster Emily Reeves Kirstin R. W. Matthews Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature Stem Cell Research & Therapy Embryoids Embryos Ethics Pluripotent stem cells Social implications Synthetic embryos |
| title | Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature |
| title_full | Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature |
| title_fullStr | Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature |
| title_full_unstemmed | Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature |
| title_short | Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature |
| title_sort | ethical legal regulatory and policy issues concerning embryoids a systematic review of the literature |
| topic | Embryoids Embryos Ethics Pluripotent stem cells Social implications Synthetic embryos |
| url | https://doi.org/10.1186/s13287-023-03448-8 |
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