Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change
<p>Mucinous tubular and spindle cell carcinoma (MTSCC) is a recent entity introduced in the World Health Organization 2004 Classification. It is a tumour of low malignant potential. MTSCC is a subtype of renal cell carcinoma (RCC), which is characterized by a polymorphous histology, wherein th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Codon Publications
2016-05-01
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| Series: | Journal of Kidney Cancer and VHL |
| Subjects: | |
| Online Access: | http://jkcvhl.com/index.php/jkcvhl/article/view/51 |
| _version_ | 1818841212238430208 |
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| author | Kafil Akhtar Pragati Agnihotri Kiran Alam Kashif Raza |
| author_facet | Kafil Akhtar Pragati Agnihotri Kiran Alam Kashif Raza |
| author_sort | Kafil Akhtar |
| collection | DOAJ |
| description | <p>Mucinous tubular and spindle cell carcinoma (MTSCC) is a recent entity introduced in the World Health Organization 2004 Classification. It is a tumour of low malignant potential. MTSCC is a subtype of renal cell carcinoma (RCC), which is characterized by a polymorphous histology, wherein the spindled epithelial cell is an inherent carcinomatous component. We report the case of a 57-year-old man presenting with loin pain and dragging sensation. Imaging revealed a large mass arising from the left kidney. Radical nephrectomy was performed, and histopathology revealed spindle cell elements of MTSCC with low-grade cytology, which occasionally blended with tubular structures in variable mucinous stroma admixed with spindle sarcomatoid cells with marked nuclear pleomorphism, associated with significant necrosis and mitoses of up to 5/10 high-power field. A final diagnosis of MTSCC along with high-grade areas consistent with sarcomatoid dedifferentiation was made. Sarcomatoid dedifferentiation has been well documented in various subtypes of RCC, and its presence signifies a worse prognosis in RCC.</p> |
| first_indexed | 2024-12-19T04:22:29Z |
| format | Article |
| id | doaj.art-7aa08979e18848089d5d24299e36f60a |
| institution | Directory Open Access Journal |
| issn | 2203-5826 |
| language | English |
| last_indexed | 2024-12-19T04:22:29Z |
| publishDate | 2016-05-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Kidney Cancer and VHL |
| spelling | doaj.art-7aa08979e18848089d5d24299e36f60a2022-12-21T20:36:07ZengCodon PublicationsJournal of Kidney Cancer and VHL2203-58262016-05-013281310.15586/jkcvhl.2016.5139Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid ChangeKafil AkhtarPragati AgnihotriKiran AlamKashif Raza<p>Mucinous tubular and spindle cell carcinoma (MTSCC) is a recent entity introduced in the World Health Organization 2004 Classification. It is a tumour of low malignant potential. MTSCC is a subtype of renal cell carcinoma (RCC), which is characterized by a polymorphous histology, wherein the spindled epithelial cell is an inherent carcinomatous component. We report the case of a 57-year-old man presenting with loin pain and dragging sensation. Imaging revealed a large mass arising from the left kidney. Radical nephrectomy was performed, and histopathology revealed spindle cell elements of MTSCC with low-grade cytology, which occasionally blended with tubular structures in variable mucinous stroma admixed with spindle sarcomatoid cells with marked nuclear pleomorphism, associated with significant necrosis and mitoses of up to 5/10 high-power field. A final diagnosis of MTSCC along with high-grade areas consistent with sarcomatoid dedifferentiation was made. Sarcomatoid dedifferentiation has been well documented in various subtypes of RCC, and its presence signifies a worse prognosis in RCC.</p>http://jkcvhl.com/index.php/jkcvhl/article/view/51Immunohistochemisrty, Kidney, Mucinous, Spindle cell carcinoma. |
| spellingShingle | Kafil Akhtar Pragati Agnihotri Kiran Alam Kashif Raza Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change Journal of Kidney Cancer and VHL Immunohistochemisrty, Kidney, Mucinous, Spindle cell carcinoma. |
| title | Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change |
| title_full | Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change |
| title_fullStr | Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change |
| title_full_unstemmed | Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change |
| title_short | Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change |
| title_sort | unusual case of coexisting renal malignancies mucinous tubular and spindle cell carcinoma kidney with sarcomatoid change |
| topic | Immunohistochemisrty, Kidney, Mucinous, Spindle cell carcinoma. |
| url | http://jkcvhl.com/index.php/jkcvhl/article/view/51 |
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