Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review
Hai-Fei Chen,1,2 Li-Ping Xu,1 Zhi-Yong Luo,1 Zi-Qiang Yu,2 Zheng-Yang Li,1 Qing-Ya Cui,1 Long-Mei Qin,1 Yong-Ya Ren,1 Hong-Shi Shen,1 Jie-Qing Tang,1 Ling-Juan Jin,1 Jing-Jing Zhu,1 Jing Wang,1 Ke-Yuan Wang,1 Tian-Qin Wu,1 Zhao-Yue Wang21Department of Hematology, 100th Hospital of People's L...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-08-01
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| Series: | Drug Design, Development and Therapy |
| Online Access: | http://www.dovepress.com/valproic-acid-associated-low-fibrinogen-and-delayed-intracranial-hemor-a14028 |
| _version_ | 1811280785483759616 |
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| author | Chen HF Xu LP Luo ZY Yu ZQ Li ZY Cui QY Qin LM Ren YY Shen HS Tang JQ Jin LJ Zhu JJ Wang J Wang KY Wu TQ Wang ZY |
| author_facet | Chen HF Xu LP Luo ZY Yu ZQ Li ZY Cui QY Qin LM Ren YY Shen HS Tang JQ Jin LJ Zhu JJ Wang J Wang KY Wu TQ Wang ZY |
| author_sort | Chen HF |
| collection | DOAJ |
| description | Hai-Fei Chen,1,2 Li-Ping Xu,1 Zhi-Yong Luo,1 Zi-Qiang Yu,2 Zheng-Yang Li,1 Qing-Ya Cui,1 Long-Mei Qin,1 Yong-Ya Ren,1 Hong-Shi Shen,1 Jie-Qing Tang,1 Ling-Juan Jin,1 Jing-Jing Zhu,1 Jing Wang,1 Ke-Yuan Wang,1 Tian-Qin Wu,1 Zhao-Yue Wang21Department of Hematology, 100th Hospital of People's Liberation Army, 2Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of ChinaAbstract: A 41-year-old male had suffered from gradual hearing loss in his right ear for 2 years. Head computed tomography and magnetic resonance imaging scans showed a neoplasm in the cerebellopontine angle region, which was confirmed by the diagnosis of acoustic neurilemmoma by pathological findings after surgery. Following surgery, he routinely received valproic acid (VPA) to prevent seizures. However, the patient presented with hypofibrinogenemia and cerebral hemorrhage after taking VPA for 12 days. The hypofibrinogenemia recurred when VPA was re-administered. After withdrawal of VPA, his fibrinogen concentration rose to normal within several days. As far as we are aware, this is the first case of cerebral hemorrhage due to VPA to have been reported. Herein, as well as reporting on this case, a mini review of the relevant literature is also presented.Keywords: side effect, hypofibrinogenemia, cerebral hemorrhage, cerebellopontine angle, neoplasm |
| first_indexed | 2024-04-13T01:21:01Z |
| format | Article |
| id | doaj.art-7aa16ec0a1704027b3d56ab8bddea450 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-04-13T01:21:01Z |
| publishDate | 2013-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-7aa16ec0a1704027b3d56ab8bddea4502022-12-22T03:08:45ZengDove Medical PressDrug Design, Development and Therapy1177-88812013-08-012013default767770Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature reviewChen HFXu LPLuo ZYYu ZQLi ZYCui QYQin LMRen YYShen HSTang JQJin LJZhu JJWang JWang KYWu TQWang ZYHai-Fei Chen,1,2 Li-Ping Xu,1 Zhi-Yong Luo,1 Zi-Qiang Yu,2 Zheng-Yang Li,1 Qing-Ya Cui,1 Long-Mei Qin,1 Yong-Ya Ren,1 Hong-Shi Shen,1 Jie-Qing Tang,1 Ling-Juan Jin,1 Jing-Jing Zhu,1 Jing Wang,1 Ke-Yuan Wang,1 Tian-Qin Wu,1 Zhao-Yue Wang21Department of Hematology, 100th Hospital of People's Liberation Army, 2Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of ChinaAbstract: A 41-year-old male had suffered from gradual hearing loss in his right ear for 2 years. Head computed tomography and magnetic resonance imaging scans showed a neoplasm in the cerebellopontine angle region, which was confirmed by the diagnosis of acoustic neurilemmoma by pathological findings after surgery. Following surgery, he routinely received valproic acid (VPA) to prevent seizures. However, the patient presented with hypofibrinogenemia and cerebral hemorrhage after taking VPA for 12 days. The hypofibrinogenemia recurred when VPA was re-administered. After withdrawal of VPA, his fibrinogen concentration rose to normal within several days. As far as we are aware, this is the first case of cerebral hemorrhage due to VPA to have been reported. Herein, as well as reporting on this case, a mini review of the relevant literature is also presented.Keywords: side effect, hypofibrinogenemia, cerebral hemorrhage, cerebellopontine angle, neoplasmhttp://www.dovepress.com/valproic-acid-associated-low-fibrinogen-and-delayed-intracranial-hemor-a14028 |
| spellingShingle | Chen HF Xu LP Luo ZY Yu ZQ Li ZY Cui QY Qin LM Ren YY Shen HS Tang JQ Jin LJ Zhu JJ Wang J Wang KY Wu TQ Wang ZY Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review Drug Design, Development and Therapy |
| title | Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review |
| title_full | Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review |
| title_fullStr | Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review |
| title_full_unstemmed | Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review |
| title_short | Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review |
| title_sort | valproic acid associated low fibrinogen and delayed intracranial hemorrhage case report and mini literature review |
| url | http://www.dovepress.com/valproic-acid-associated-low-fibrinogen-and-delayed-intracranial-hemor-a14028 |
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