Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus)
Abstract Background Chicken is one of the most numerous and widely distributed species around the world, and many studies support the multiple ancestral origins of domestic chickens. The research regarding the yellow skin phenotype in domestic chickens (regulated by BCO2) likely originating from the...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Animal Science and Biotechnology |
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| Online Access: | https://doi.org/10.1186/s40104-024-01006-7 |
| _version_ | 1797219672405311488 |
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| author | Xiurong Zhao Junhui Wen Xinye Zhang Jinxin Zhang Tao Zhu Huie Wang Weifang Yang Guomin Cao Wenjie Xiong Yong Liu Changqing Qu Zhonghua Ning Lujiang Qu |
| author_facet | Xiurong Zhao Junhui Wen Xinye Zhang Jinxin Zhang Tao Zhu Huie Wang Weifang Yang Guomin Cao Wenjie Xiong Yong Liu Changqing Qu Zhonghua Ning Lujiang Qu |
| author_sort | Xiurong Zhao |
| collection | DOAJ |
| description | Abstract Background Chicken is one of the most numerous and widely distributed species around the world, and many studies support the multiple ancestral origins of domestic chickens. The research regarding the yellow skin phenotype in domestic chickens (regulated by BCO2) likely originating from the grey junglefowl serves as crucial evidence for demonstrating the multiple origins of chickens. However, beyond the BCO2 gene region, much remains unknown about the introgression from the grey junglefowl into domestic chickens. Therefore, in this study, based on whole-genome data of 149 samples including 4 species of wild junglefowls and 13 local domestic chicken breeds, we explored the introgression events from the grey junglefowl to domestic chickens. Results We successfully detected introgression regions besides BCO2, including two associated with growth trait (IGFBP2 and TKT), one associated with angiogenesis (TIMP3) and two members of the heat shock protein family (HSPB2 and CRYAB). Our findings suggest that the introgression from the grey junglefowl may impact the growth performance of chickens. Furthermore, we revealed introgression events from grey junglefowl at the BCO2 region in multiple domestic chicken breeds, indicating a phenomenon where the yellow skin phenotype likely underwent strong selection and was retained. Additionally, our haplotype analysis shed light on BCO2 introgression event from different sources of grey junglefowl into domestic chickens, possibly suggesting multiple genetic flows between the grey junglefowl and domestic chickens. Conclusions In summary, our findings provide evidences of the grey junglefowl contributing to the genetic diversity of domestic chickens, laying the foundation for a deeper understanding of the genetic composition within domestic chickens, and offering new perspectives on the impact of introgression on domestic chickens. |
| first_indexed | 2024-04-24T12:37:22Z |
| format | Article |
| id | doaj.art-7aa2195eb2e248bc8af3e579b4675aae |
| institution | Directory Open Access Journal |
| issn | 2049-1891 |
| language | English |
| last_indexed | 2024-04-24T12:37:22Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Animal Science and Biotechnology |
| spelling | doaj.art-7aa2195eb2e248bc8af3e579b4675aae2024-04-07T11:26:34ZengBMCJournal of Animal Science and Biotechnology2049-18912024-04-0115111210.1186/s40104-024-01006-7Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus)Xiurong Zhao0Junhui Wen1Xinye Zhang2Jinxin Zhang3Tao Zhu4Huie Wang5Weifang Yang6Guomin Cao7Wenjie Xiong8Yong Liu9Changqing Qu10Zhonghua Ning11Lujiang Qu12National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityKey Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Corps, Tarim UniversityBeijing Municipal General Station of Animal ScienceAnimal husbandry station of FangchenggangAnimal Disease Prevention and Control Center of FangchenggangBeijing Agricultural Effect Poultry Industry Co., Ltd.Engineering Technology Research Center of Anti-aging Chinese Herbal Medicine of Anhui Province, Fuyang Normal UniversityNational Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityNational Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityAbstract Background Chicken is one of the most numerous and widely distributed species around the world, and many studies support the multiple ancestral origins of domestic chickens. The research regarding the yellow skin phenotype in domestic chickens (regulated by BCO2) likely originating from the grey junglefowl serves as crucial evidence for demonstrating the multiple origins of chickens. However, beyond the BCO2 gene region, much remains unknown about the introgression from the grey junglefowl into domestic chickens. Therefore, in this study, based on whole-genome data of 149 samples including 4 species of wild junglefowls and 13 local domestic chicken breeds, we explored the introgression events from the grey junglefowl to domestic chickens. Results We successfully detected introgression regions besides BCO2, including two associated with growth trait (IGFBP2 and TKT), one associated with angiogenesis (TIMP3) and two members of the heat shock protein family (HSPB2 and CRYAB). Our findings suggest that the introgression from the grey junglefowl may impact the growth performance of chickens. Furthermore, we revealed introgression events from grey junglefowl at the BCO2 region in multiple domestic chicken breeds, indicating a phenomenon where the yellow skin phenotype likely underwent strong selection and was retained. Additionally, our haplotype analysis shed light on BCO2 introgression event from different sources of grey junglefowl into domestic chickens, possibly suggesting multiple genetic flows between the grey junglefowl and domestic chickens. Conclusions In summary, our findings provide evidences of the grey junglefowl contributing to the genetic diversity of domestic chickens, laying the foundation for a deeper understanding of the genetic composition within domestic chickens, and offering new perspectives on the impact of introgression on domestic chickens.https://doi.org/10.1186/s40104-024-01006-7BCO2Domestic chickensGrey junglefowlIntrogression |
| spellingShingle | Xiurong Zhao Junhui Wen Xinye Zhang Jinxin Zhang Tao Zhu Huie Wang Weifang Yang Guomin Cao Wenjie Xiong Yong Liu Changqing Qu Zhonghua Ning Lujiang Qu Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) Journal of Animal Science and Biotechnology BCO2 Domestic chickens Grey junglefowl Introgression |
| title | Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) |
| title_full | Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) |
| title_fullStr | Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) |
| title_full_unstemmed | Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) |
| title_short | Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus) |
| title_sort | significant genomic introgression from grey junglefowl gallus sonneratii to domestic chickens gallus gallus domesticus |
| topic | BCO2 Domestic chickens Grey junglefowl Introgression |
| url | https://doi.org/10.1186/s40104-024-01006-7 |
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