Gastric juice non-coding RNAs as potential biomarkers for gastric cancer
Gastric cancer (GC), being one of the most common malignant human tumors, occupies the second position in the structure of mortality in men and women. High rates of morbidity and mortality in this pathology determine its extremely high clinical and social significance. Diagnosis and timely treatment...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1179582/full |
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| author | Ilgiz Gareev Aamir Ahmad Jiaqi Wang Aferin Beilerli Tatiana Ilyasova Albert Sufianov Albert Sufianov Ozal Beylerli |
| author_facet | Ilgiz Gareev Aamir Ahmad Jiaqi Wang Aferin Beilerli Tatiana Ilyasova Albert Sufianov Albert Sufianov Ozal Beylerli |
| author_sort | Ilgiz Gareev |
| collection | DOAJ |
| description | Gastric cancer (GC), being one of the most common malignant human tumors, occupies the second position in the structure of mortality in men and women. High rates of morbidity and mortality in this pathology determine its extremely high clinical and social significance. Diagnosis and timely treatment of precancerous pathology is the main way to reduce morbidity and mortality, and early detection of GC and its adequate treatment improve prognosis. The ability to accurately predict the development of GC and start treatment on time, as well as the ability to determine the stage of the disease if the diagnosis is confirmed - non-invasive biomarkers can become the key to solving these and many other problems of modern medicine. One of the promising biomarkers being studied are non-coding RNAs, namely, miсroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). They are involved in a wide range of processes, including apoptosis, proliferation, differentiation, angiogenesis, which play a critical role in the development of GC oncogenesis. In addition, they are quite specific and stable due to their carriers (extracellular vesicles or Argonaute 2 protein) and can be detected in various human biological fluids, in particular gastric juice. Thus, miRNAs, lncRNAs, and circRNAs isolated from the gastric juice of GC patients are promising preventive, diagnostic and prognostic non-invasive biomarkers. This review article presents the characteristics of circulating or extracellular miRNAs, lncRNAs, and circRNAs in gastric juice, allowing their use in the GC preventive, diagnosis, prognosis and monitoring therapy. |
| first_indexed | 2024-03-13T10:52:22Z |
| format | Article |
| id | doaj.art-7aa2ca876c14411faa026816567f53eb |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-13T10:52:22Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7aa2ca876c14411faa026816567f53eb2023-05-17T11:21:04ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-04-011410.3389/fphys.2023.11795821179582Gastric juice non-coding RNAs as potential biomarkers for gastric cancerIlgiz Gareev0Aamir Ahmad1Jiaqi Wang2Aferin Beilerli3Tatiana Ilyasova4Albert Sufianov5Albert Sufianov6Ozal Beylerli7Educational and Scientific Institute of Neurosurgery, Peoples’ Friendship University of Russia (RUDN University), Moscow, RussianAcademic Health System, Hamad Medical Corporation, Interim Translational Research Institute, Doha, QatarDepartment of Urology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Obstetrics and Gynecology, Tyumen State Medical University, Tyumen, RussiaDepartment of Internal Diseases, Bashkir State Medical University, Ufa, RussiaEducational and Scientific Institute of Neurosurgery, Peoples’ Friendship University of Russia (RUDN University), Moscow, RussianDepartment of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaEducational and Scientific Institute of Neurosurgery, Peoples’ Friendship University of Russia (RUDN University), Moscow, RussianGastric cancer (GC), being one of the most common malignant human tumors, occupies the second position in the structure of mortality in men and women. High rates of morbidity and mortality in this pathology determine its extremely high clinical and social significance. Diagnosis and timely treatment of precancerous pathology is the main way to reduce morbidity and mortality, and early detection of GC and its adequate treatment improve prognosis. The ability to accurately predict the development of GC and start treatment on time, as well as the ability to determine the stage of the disease if the diagnosis is confirmed - non-invasive biomarkers can become the key to solving these and many other problems of modern medicine. One of the promising biomarkers being studied are non-coding RNAs, namely, miсroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). They are involved in a wide range of processes, including apoptosis, proliferation, differentiation, angiogenesis, which play a critical role in the development of GC oncogenesis. In addition, they are quite specific and stable due to their carriers (extracellular vesicles or Argonaute 2 protein) and can be detected in various human biological fluids, in particular gastric juice. Thus, miRNAs, lncRNAs, and circRNAs isolated from the gastric juice of GC patients are promising preventive, diagnostic and prognostic non-invasive biomarkers. This review article presents the characteristics of circulating or extracellular miRNAs, lncRNAs, and circRNAs in gastric juice, allowing their use in the GC preventive, diagnosis, prognosis and monitoring therapy.https://www.frontiersin.org/articles/10.3389/fphys.2023.1179582/fullgastric juice ncRNAs and gastric cancer non-coding RNAsgastric cancergastric juiceliquid biopsynon-invasive biomarkersextracellular vesicles |
| spellingShingle | Ilgiz Gareev Aamir Ahmad Jiaqi Wang Aferin Beilerli Tatiana Ilyasova Albert Sufianov Albert Sufianov Ozal Beylerli Gastric juice non-coding RNAs as potential biomarkers for gastric cancer Frontiers in Physiology gastric juice ncRNAs and gastric cancer non-coding RNAs gastric cancer gastric juice liquid biopsy non-invasive biomarkers extracellular vesicles |
| title | Gastric juice non-coding RNAs as potential biomarkers for gastric cancer |
| title_full | Gastric juice non-coding RNAs as potential biomarkers for gastric cancer |
| title_fullStr | Gastric juice non-coding RNAs as potential biomarkers for gastric cancer |
| title_full_unstemmed | Gastric juice non-coding RNAs as potential biomarkers for gastric cancer |
| title_short | Gastric juice non-coding RNAs as potential biomarkers for gastric cancer |
| title_sort | gastric juice non coding rnas as potential biomarkers for gastric cancer |
| topic | gastric juice ncRNAs and gastric cancer non-coding RNAs gastric cancer gastric juice liquid biopsy non-invasive biomarkers extracellular vesicles |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1179582/full |
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