Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption
Orthodontic-induced external apical root resorption (EARR) is a severe condition affecting the roots of the teeth, whose genetic causes have been inconclusive to date. The aim of the present study was to assess the influence of selected single nucleotide polymorphisms (SNPs) IL-1β, TNFRSF11B, CASP1,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/18/4166 |
| _version_ | 1797518743260102656 |
|---|---|
| author | Agata Ciurla Crystal Marruganti Tiziana Doldo Jolanta Szymańska |
| author_facet | Agata Ciurla Crystal Marruganti Tiziana Doldo Jolanta Szymańska |
| author_sort | Agata Ciurla |
| collection | DOAJ |
| description | Orthodontic-induced external apical root resorption (EARR) is a severe condition affecting the roots of the teeth, whose genetic causes have been inconclusive to date. The aim of the present study was to assess the influence of selected single nucleotide polymorphisms (SNPs) IL-1β, TNFRSF11B, CASP1, and IL-6 genes on post-orthodontic EARR. A sample of 101 patients with clearly assessable orthopantomograms and lateral cephalometric radiographs taken before and at the end of the orthodontic treatment was used to evaluate the presence of EARR. The association between genetic polymorphisms and EARR was assessed with the Chi<sup>2</sup> test. A binary logistic multi-level model was built to evaluate the ability of patient- and tooth-level variables to predict EARR occurrence. The overall prevalence of EARR resulted to be around 40%. Within the limitations of this study, a significant association was found between EARR presence and the SNP for the IL-1β gene but not for the TNFRSF11B, CASP1, and the IL-6 genes. The final multi-level model demonstrated that the SNP for the IL-1β gene increases the odds of developing EARR by around four times. Since there is currently no accurate method to determine which patients will develop EARR prior to orthodontic treatment, further studies are needed to investigate the predictive ability of further genetic variants on EARR development. |
| first_indexed | 2024-03-10T07:33:55Z |
| format | Article |
| id | doaj.art-7aa30d48268b4b2493a35767e3d6027b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:33:55Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7aa30d48268b4b2493a35767e3d6027b2023-11-22T13:40:43ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018416610.3390/jcm10184166Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root ResorptionAgata Ciurla0Crystal Marruganti1Tiziana Doldo2Jolanta Szymańska3Dentist’s Office ORTO-PUNKT, Mościckiego St. 72/1, 33-100 Tarnów, PolandUnit of Periodontology, Endodontology, Restorative and Pediatric Dentistry, Department of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyUnit of Orthodontics, Department of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyComprehensive Dentistry, Department of Comprehensive Paediatric and Adult Dentistry, Medical University of Lublin, 6 Chodźki St., 20-093 Lublin, PolandOrthodontic-induced external apical root resorption (EARR) is a severe condition affecting the roots of the teeth, whose genetic causes have been inconclusive to date. The aim of the present study was to assess the influence of selected single nucleotide polymorphisms (SNPs) IL-1β, TNFRSF11B, CASP1, and IL-6 genes on post-orthodontic EARR. A sample of 101 patients with clearly assessable orthopantomograms and lateral cephalometric radiographs taken before and at the end of the orthodontic treatment was used to evaluate the presence of EARR. The association between genetic polymorphisms and EARR was assessed with the Chi<sup>2</sup> test. A binary logistic multi-level model was built to evaluate the ability of patient- and tooth-level variables to predict EARR occurrence. The overall prevalence of EARR resulted to be around 40%. Within the limitations of this study, a significant association was found between EARR presence and the SNP for the IL-1β gene but not for the TNFRSF11B, CASP1, and the IL-6 genes. The final multi-level model demonstrated that the SNP for the IL-1β gene increases the odds of developing EARR by around four times. Since there is currently no accurate method to determine which patients will develop EARR prior to orthodontic treatment, further studies are needed to investigate the predictive ability of further genetic variants on EARR development.https://www.mdpi.com/2077-0383/10/18/4166gene polymorphismroot resorptionorthodontic treatment |
| spellingShingle | Agata Ciurla Crystal Marruganti Tiziana Doldo Jolanta Szymańska Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption Journal of Clinical Medicine gene polymorphism root resorption orthodontic treatment |
| title | Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption |
| title_full | Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption |
| title_fullStr | Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption |
| title_full_unstemmed | Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption |
| title_short | Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption |
| title_sort | association between polymorphisms in the il 1β tnfrsf11b casp1 and il 6 genes and orthodontic induced external apical root resorption |
| topic | gene polymorphism root resorption orthodontic treatment |
| url | https://www.mdpi.com/2077-0383/10/18/4166 |
| work_keys_str_mv | AT agataciurla associationbetweenpolymorphismsintheil1btnfrsf11bcasp1andil6genesandorthodonticinducedexternalapicalrootresorption AT crystalmarruganti associationbetweenpolymorphismsintheil1btnfrsf11bcasp1andil6genesandorthodonticinducedexternalapicalrootresorption AT tizianadoldo associationbetweenpolymorphismsintheil1btnfrsf11bcasp1andil6genesandorthodonticinducedexternalapicalrootresorption AT jolantaszymanska associationbetweenpolymorphismsintheil1btnfrsf11bcasp1andil6genesandorthodonticinducedexternalapicalrootresorption |