Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia
Purpose The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in t...
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/6/e069258.full |
| _version_ | 1827154623598690304 |
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| author | Martin McKibbin Tariq Aslam Sarah Barman Jenny Barrett Paul Bishop Roxana Carare Usha Chakravarthy Michelle Chan Alexander Day Parul Desai Bal Dhillon Andrew Dick Cathy Egan Sarah Ennis Paul Foster Marcus Fruttiger John Gallacher Jane Gibson Jeremy Guggenheim Chris Hammond Alison Hardcastle Simon Harding Ruth Hogg Pirro Hysi Anthony Khawaja Gerassimos Lascaratos Andrew Lotery Phil Luthert Tom Macgillivray Sarah Mackie Bernadette Mcguinness Gareth Mckay Tony Moore James Morgan Eoin O’sullivan Chris Owen Praveen Patel Euan Paterson Axel Petzold Alicja Rudnicka Paul J Foster Naomi Allen Peng Tee Khaw Praveen J Patel Konstantinos Balaskas Richard Oram Robert Luben Tasanee Braithwaite Graeme Black Christopher G Owen Zihan Sun David Garway-Heath Thomas Littlejohns Simon Sheard Sharon Chua Pearse Keane Denize Atan Savita Madhusudhan Alexander Doney |
| author_facet | Martin McKibbin Tariq Aslam Sarah Barman Jenny Barrett Paul Bishop Roxana Carare Usha Chakravarthy Michelle Chan Alexander Day Parul Desai Bal Dhillon Andrew Dick Cathy Egan Sarah Ennis Paul Foster Marcus Fruttiger John Gallacher Jane Gibson Jeremy Guggenheim Chris Hammond Alison Hardcastle Simon Harding Ruth Hogg Pirro Hysi Anthony Khawaja Gerassimos Lascaratos Andrew Lotery Phil Luthert Tom Macgillivray Sarah Mackie Bernadette Mcguinness Gareth Mckay Tony Moore James Morgan Eoin O’sullivan Chris Owen Praveen Patel Euan Paterson Axel Petzold Alicja Rudnicka Paul J Foster Naomi Allen Peng Tee Khaw Praveen J Patel Konstantinos Balaskas Richard Oram Robert Luben Tasanee Braithwaite Graeme Black Christopher G Owen Zihan Sun David Garway-Heath Thomas Littlejohns Simon Sheard Sharon Chua Pearse Keane Denize Atan Savita Madhusudhan Alexander Doney |
| collection | DOAJ |
| description | Purpose The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in the UK Biobank Repeat Imaging study.Participants UK Biobank is a large-scale, multicentre, prospective cohort containing in-depth genetic, lifestyle, environmental and health information from half a million participants aged 40–69 enrolled in 2006–2010 across the UK. A subset (up to 60 000 participants) of the cohort will be invited to the UK Biobank Repeat Imaging Study to collect repeated brain, cardiac and abdominal MRI scans, whole-body dual-energy X-ray absorptiometry, carotid ultrasound, as well as retinal optical coherence tomography (OCT) and colour fundus photographs.Findings to date UK Biobank has helped make significant advances in understanding risk factors for many common diseases, including for dementia and cognitive decline. Ophthalmic genetic and epidemiology studies have also benefited from the unparalleled combination of very large numbers of participants, deep phenotyping and longitudinal follow-up of the cohort, with comprehensive health data linkage to disease outcomes. In addition, we have used UK Biobank data to describe the relationship between retinal structures, cognitive function and brain MRI-derived phenotypes.Future plans The collection of eye-related data (eg, OCT), as part of the UK Biobank Repeat Imaging study, will take place in 2022–2028. The depth and breadth and longitudinal nature of this dataset, coupled with its open-access policy, will create a major new resource for dementia diagnostic discovery and to better understand its association with comorbid diseases. In addition, the broad and diverse data available in this study will support research into ophthalmic diseases and various other health outcomes beyond dementia. |
| first_indexed | 2024-03-12T14:27:24Z |
| format | Article |
| id | doaj.art-7aa3818d8e5e4fc3b026f8c7a9faa59c |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-03-20T22:40:36Z |
| publishDate | 2023-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-7aa3818d8e5e4fc3b026f8c7a9faa59c2024-08-06T15:25:11ZengBMJ Publishing GroupBMJ Open2044-60552023-06-0113610.1136/bmjopen-2022-069258Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia 0Martin McKibbinTariq AslamSarah BarmanJenny BarrettPaul BishopRoxana CarareUsha ChakravarthyMichelle ChanAlexander DayParul DesaiBal DhillonAndrew Dick1Cathy EganSarah EnnisPaul FosterMarcus FruttigerJohn GallacherJane GibsonJeremy GuggenheimChris HammondAlison HardcastleSimon HardingRuth HoggPirro HysiAnthony Khawaja2Gerassimos LascaratosAndrew Lotery3Phil LuthertTom Macgillivray4Sarah MackieBernadette Mcguinness5Gareth MckayTony MooreJames MorganEoin O’sullivanChris OwenPraveen PatelEuan PatersonAxel Petzold6Alicja Rudnicka7Paul J Foster8Naomi Allen9Peng Tee KhawPraveen J Patel10Konstantinos BalaskasRichard OramRobert LubenTasanee BraithwaiteGraeme BlackChristopher G Owen11Zihan Sun12David Garway-Heath13Thomas LittlejohnsSimon Sheard14Sharon ChuaPearse KeaneDenize Atan15Savita MadhusudhanAlexander DoneySchool of Medicine, Cardiff University, Cardiff, UKUniversity of Bristol, Bristol, UK3 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK4 Faculty of Medicine, University of Southampton, Southampton, UK5 Clinical Research Imaging Centre, Queens Medical Research Institution, Edinburgh, UKCentre for Public Health, Queen`s University Belfast, Belfast, UKMS Center and Neuro-ophthalmology Expertise Center Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, Noord-Holland, The Netherlands6 Population Health Research Institute, St Georges Medical School, University of London, London, UK1 Moorfields Eye Hospital NHS Foundation Trust, NIHR Moorfields Biomedical Research Centre, London, UK11 UK Biobank, Stockport, UK7 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK6 Population Health Research Institute, St Georges Medical School, University of London, London, UK10 Institute of Ophthalmology, University College London, London, UKGlaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK11 UK Biobank, Stockport, UK2 Medical School, University of Bristol, Bristol, UKPurpose The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in the UK Biobank Repeat Imaging study.Participants UK Biobank is a large-scale, multicentre, prospective cohort containing in-depth genetic, lifestyle, environmental and health information from half a million participants aged 40–69 enrolled in 2006–2010 across the UK. A subset (up to 60 000 participants) of the cohort will be invited to the UK Biobank Repeat Imaging Study to collect repeated brain, cardiac and abdominal MRI scans, whole-body dual-energy X-ray absorptiometry, carotid ultrasound, as well as retinal optical coherence tomography (OCT) and colour fundus photographs.Findings to date UK Biobank has helped make significant advances in understanding risk factors for many common diseases, including for dementia and cognitive decline. Ophthalmic genetic and epidemiology studies have also benefited from the unparalleled combination of very large numbers of participants, deep phenotyping and longitudinal follow-up of the cohort, with comprehensive health data linkage to disease outcomes. In addition, we have used UK Biobank data to describe the relationship between retinal structures, cognitive function and brain MRI-derived phenotypes.Future plans The collection of eye-related data (eg, OCT), as part of the UK Biobank Repeat Imaging study, will take place in 2022–2028. The depth and breadth and longitudinal nature of this dataset, coupled with its open-access policy, will create a major new resource for dementia diagnostic discovery and to better understand its association with comorbid diseases. In addition, the broad and diverse data available in this study will support research into ophthalmic diseases and various other health outcomes beyond dementia.https://bmjopen.bmj.com/content/13/6/e069258.full |
| spellingShingle | Martin McKibbin Tariq Aslam Sarah Barman Jenny Barrett Paul Bishop Roxana Carare Usha Chakravarthy Michelle Chan Alexander Day Parul Desai Bal Dhillon Andrew Dick Cathy Egan Sarah Ennis Paul Foster Marcus Fruttiger John Gallacher Jane Gibson Jeremy Guggenheim Chris Hammond Alison Hardcastle Simon Harding Ruth Hogg Pirro Hysi Anthony Khawaja Gerassimos Lascaratos Andrew Lotery Phil Luthert Tom Macgillivray Sarah Mackie Bernadette Mcguinness Gareth Mckay Tony Moore James Morgan Eoin O’sullivan Chris Owen Praveen Patel Euan Paterson Axel Petzold Alicja Rudnicka Paul J Foster Naomi Allen Peng Tee Khaw Praveen J Patel Konstantinos Balaskas Richard Oram Robert Luben Tasanee Braithwaite Graeme Black Christopher G Owen Zihan Sun David Garway-Heath Thomas Littlejohns Simon Sheard Sharon Chua Pearse Keane Denize Atan Savita Madhusudhan Alexander Doney Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia BMJ Open |
| title | Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia |
| title_full | Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia |
| title_fullStr | Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia |
| title_full_unstemmed | Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia |
| title_short | Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia |
| title_sort | cohort profile rationale and methods of uk biobank repeat imaging study eye measures to study dementia |
| url | https://bmjopen.bmj.com/content/13/6/e069258.full |
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