Immune cells and related cytokines in dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more underlying etiologies. It is characterized by structural and functional dysfunction of the myocardium, potentially leading to fibrosis and ventricular remodeling, and an elevated risk of heart failure (HF). Although...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224000404 |
| _version_ | 1797324341362294784 |
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| author | Jingdi Zhang Linlin Cheng Zhan Li Haolong Li Yongmei Liu Haoting Zhan Honglin Xu Yuan Huang Futai Feng Yongzhe Li |
| author_facet | Jingdi Zhang Linlin Cheng Zhan Li Haolong Li Yongmei Liu Haoting Zhan Honglin Xu Yuan Huang Futai Feng Yongzhe Li |
| author_sort | Jingdi Zhang |
| collection | DOAJ |
| description | Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more underlying etiologies. It is characterized by structural and functional dysfunction of the myocardium, potentially leading to fibrosis and ventricular remodeling, and an elevated risk of heart failure (HF). Although the pathogenesis of DCM remains unknown, compelling evidence suggests that DCM-triggered immune cells and inflammatory cascades play a crucial role in the occurrence and development of DCM. Various factors are linked to myocardial damage, inducing aberrant activation of the immune system and sustained inflammatory responses in DCM. The investigation of the immunopathogenesis of DCM also contributes to discovering new biomarkers and therapeutic targets. This review examines the roles of immune cells and related cytokines in DCM pathogenesis and explores immunotherapy strategies in DCM. |
| first_indexed | 2024-03-08T05:54:44Z |
| format | Article |
| id | doaj.art-7aa8b35aeb0c4a65978162168e986c87 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T05:54:44Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7aa8b35aeb0c4a65978162168e986c872024-02-05T04:31:19ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-02-01171116159Immune cells and related cytokines in dilated cardiomyopathyJingdi Zhang0Linlin Cheng1Zhan Li2Haolong Li3Yongmei Liu4Haoting Zhan5Honglin Xu6Yuan Huang7Futai Feng8Yongzhe Li9Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaCorresponding author.; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more underlying etiologies. It is characterized by structural and functional dysfunction of the myocardium, potentially leading to fibrosis and ventricular remodeling, and an elevated risk of heart failure (HF). Although the pathogenesis of DCM remains unknown, compelling evidence suggests that DCM-triggered immune cells and inflammatory cascades play a crucial role in the occurrence and development of DCM. Various factors are linked to myocardial damage, inducing aberrant activation of the immune system and sustained inflammatory responses in DCM. The investigation of the immunopathogenesis of DCM also contributes to discovering new biomarkers and therapeutic targets. This review examines the roles of immune cells and related cytokines in DCM pathogenesis and explores immunotherapy strategies in DCM.http://www.sciencedirect.com/science/article/pii/S0753332224000404Dilated cardiomyopathyImmune cellsCytokinesPathogenesisImmunotherapy strategies |
| spellingShingle | Jingdi Zhang Linlin Cheng Zhan Li Haolong Li Yongmei Liu Haoting Zhan Honglin Xu Yuan Huang Futai Feng Yongzhe Li Immune cells and related cytokines in dilated cardiomyopathy Biomedicine & Pharmacotherapy Dilated cardiomyopathy Immune cells Cytokines Pathogenesis Immunotherapy strategies |
| title | Immune cells and related cytokines in dilated cardiomyopathy |
| title_full | Immune cells and related cytokines in dilated cardiomyopathy |
| title_fullStr | Immune cells and related cytokines in dilated cardiomyopathy |
| title_full_unstemmed | Immune cells and related cytokines in dilated cardiomyopathy |
| title_short | Immune cells and related cytokines in dilated cardiomyopathy |
| title_sort | immune cells and related cytokines in dilated cardiomyopathy |
| topic | Dilated cardiomyopathy Immune cells Cytokines Pathogenesis Immunotherapy strategies |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224000404 |
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