Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights
Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/3/4/53 |
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| author | Kushagra Nagori Kartik T. Nakhate Krishna Yadav Ajazuddin Madhulika Pradhan |
| author_facet | Kushagra Nagori Kartik T. Nakhate Krishna Yadav Ajazuddin Madhulika Pradhan |
| author_sort | Kushagra Nagori |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient therapeutic strategies are essential. Moreover, the progression of the disease is unaffected by the pharmaceutical approaches discovered to date. Additionally, the failure of over 200 potential drug candidates in clinical trials over the past decade suggests the complexity and difficulty of both the disease and its underlying causes. Therefore, research focused on medicinal plant-based natural products in the search for novel neuroprotective therapeutic candidates for AD is essential. Indeed, several scientific investigations have demonstrated the efficacy of many medicinal plants and their principal phytochemicals in the treatment of AD. This review article covered the pathophysiological mechanisms of AD, the necessity for natural products as anti-AD treatments, and the most recent preclinical studies revealing the function of neuroprotective medicinal plants and their bioactive compounds in the effective management of AD. In addition, the review also presents clinical trial data of promising anti-AD formulations/agents of plant origin. Revealing recent findings and highlighting the clinical trial data related to the development of new treatments for AD would promote further research in this field and pave the way for the development of more effective and safe treatments for this debilitating disease. |
| first_indexed | 2024-03-08T20:44:50Z |
| format | Article |
| id | doaj.art-7aaa2d6379364804aabeab3929c7a127 |
| institution | Directory Open Access Journal |
| issn | 2673-9879 |
| language | English |
| last_indexed | 2024-03-08T20:44:50Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj.art-7aaa2d6379364804aabeab3929c7a1272023-12-22T14:10:17ZengMDPI AGFuture Pharmacology2673-98792023-11-013487790710.3390/futurepharmacol3040053Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial InsightsKushagra Nagori0Kartik T. Nakhate1Krishna Yadav2Ajazuddin3Madhulika Pradhan4Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai 490024, IndiaDepartment of Pharmacology, Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule 424001, IndiaRaipur Institute of Pharmaceutical Education and Research, Raipur 492010, IndiaRungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai 490024, IndiaGracious College of Pharmacy, Abhanpur, Raipur 493661, IndiaAlzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient therapeutic strategies are essential. Moreover, the progression of the disease is unaffected by the pharmaceutical approaches discovered to date. Additionally, the failure of over 200 potential drug candidates in clinical trials over the past decade suggests the complexity and difficulty of both the disease and its underlying causes. Therefore, research focused on medicinal plant-based natural products in the search for novel neuroprotective therapeutic candidates for AD is essential. Indeed, several scientific investigations have demonstrated the efficacy of many medicinal plants and their principal phytochemicals in the treatment of AD. This review article covered the pathophysiological mechanisms of AD, the necessity for natural products as anti-AD treatments, and the most recent preclinical studies revealing the function of neuroprotective medicinal plants and their bioactive compounds in the effective management of AD. In addition, the review also presents clinical trial data of promising anti-AD formulations/agents of plant origin. Revealing recent findings and highlighting the clinical trial data related to the development of new treatments for AD would promote further research in this field and pave the way for the development of more effective and safe treatments for this debilitating disease.https://www.mdpi.com/2673-9879/3/4/53neuroprotectiveAlzheimer’s disease (AD)medicinal plantsclinical trial |
| spellingShingle | Kushagra Nagori Kartik T. Nakhate Krishna Yadav Ajazuddin Madhulika Pradhan Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights Future Pharmacology neuroprotective Alzheimer’s disease (AD) medicinal plants clinical trial |
| title | Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights |
| title_full | Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights |
| title_fullStr | Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights |
| title_full_unstemmed | Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights |
| title_short | Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights |
| title_sort | unlocking the therapeutic potential of medicinal plants for alzheimer s disease preclinical to clinical trial insights |
| topic | neuroprotective Alzheimer’s disease (AD) medicinal plants clinical trial |
| url | https://www.mdpi.com/2673-9879/3/4/53 |
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