Isolated reversible toxic optic neuropathy secondary to linezolid
A 67-year-old male diagnosed with methicillin-resistant Staphylococcus aureus-induced osteomyelitis was started on second-line antibiotic therapy (linezolid). One year following initiation of treatment, he presented to the emergency room with bilateral painless acute deterioration in vision. Visual...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Clinical Ophthalmology and Research |
| Subjects: | |
| Online Access: | http://www.jcor.in/article.asp?issn=2320-3897;year=2017;volume=5;issue=1;spage=40;epage=42;aulast=Berkovitz |
| _version_ | 1818844754348081152 |
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| author | Liron Berkovitz Irena Krasnitz Itzchak Beiran Eytan Z Blumenthal Michael Mimouni |
| author_facet | Liron Berkovitz Irena Krasnitz Itzchak Beiran Eytan Z Blumenthal Michael Mimouni |
| author_sort | Liron Berkovitz |
| collection | DOAJ |
| description | A 67-year-old male diagnosed with methicillin-resistant Staphylococcus aureus-induced osteomyelitis was started on second-line antibiotic therapy (linezolid). One year following initiation of treatment, he presented to the emergency room with bilateral painless acute deterioration in vision. Visual field testing suggested bilateral optic neuropathy. Following cessation of linezolid visual acuity and visual fields reverted to normal. A handful of case reports has described reversible optic neuropathy occurring shortly after initialization of linezolid treatment. This is, to the best of our knowledge, the first report of isolated delayed onset reversible optic neuropathy with concomitant use of linezolid unaccompanied by any other systemic toxic manifestations. Reversible optic neuropathy may occur in patients receiving long-term linezolid treatment. Ophthalmic follow-up including visual field testing in patients receiving long-term linezolid treatment may assist in early recognition. |
| first_indexed | 2024-12-19T05:18:47Z |
| format | Article |
| id | doaj.art-7aaa785c94a34fd7a2106cd208c87a70 |
| institution | Directory Open Access Journal |
| issn | 2320-3897 |
| language | English |
| last_indexed | 2024-12-19T05:18:47Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj.art-7aaa785c94a34fd7a2106cd208c87a702022-12-21T20:34:34ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972017-01-0151404210.4103/2320-3897.195309Isolated reversible toxic optic neuropathy secondary to linezolidLiron BerkovitzIrena KrasnitzItzchak BeiranEytan Z BlumenthalMichael MimouniA 67-year-old male diagnosed with methicillin-resistant Staphylococcus aureus-induced osteomyelitis was started on second-line antibiotic therapy (linezolid). One year following initiation of treatment, he presented to the emergency room with bilateral painless acute deterioration in vision. Visual field testing suggested bilateral optic neuropathy. Following cessation of linezolid visual acuity and visual fields reverted to normal. A handful of case reports has described reversible optic neuropathy occurring shortly after initialization of linezolid treatment. This is, to the best of our knowledge, the first report of isolated delayed onset reversible optic neuropathy with concomitant use of linezolid unaccompanied by any other systemic toxic manifestations. Reversible optic neuropathy may occur in patients receiving long-term linezolid treatment. Ophthalmic follow-up including visual field testing in patients receiving long-term linezolid treatment may assist in early recognition.http://www.jcor.in/article.asp?issn=2320-3897;year=2017;volume=5;issue=1;spage=40;epage=42;aulast=BerkovitzLinezolidmethicillin-resistant Staphylococcus aureusoptic neuropathyosteomyelitis |
| spellingShingle | Liron Berkovitz Irena Krasnitz Itzchak Beiran Eytan Z Blumenthal Michael Mimouni Isolated reversible toxic optic neuropathy secondary to linezolid Journal of Clinical Ophthalmology and Research Linezolid methicillin-resistant Staphylococcus aureus optic neuropathy osteomyelitis |
| title | Isolated reversible toxic optic neuropathy secondary to linezolid |
| title_full | Isolated reversible toxic optic neuropathy secondary to linezolid |
| title_fullStr | Isolated reversible toxic optic neuropathy secondary to linezolid |
| title_full_unstemmed | Isolated reversible toxic optic neuropathy secondary to linezolid |
| title_short | Isolated reversible toxic optic neuropathy secondary to linezolid |
| title_sort | isolated reversible toxic optic neuropathy secondary to linezolid |
| topic | Linezolid methicillin-resistant Staphylococcus aureus optic neuropathy osteomyelitis |
| url | http://www.jcor.in/article.asp?issn=2320-3897;year=2017;volume=5;issue=1;spage=40;epage=42;aulast=Berkovitz |
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