Development of the multi-attribute Adolescent Health Utility Measure (AHUM)
<p>Abstract</p> <p>Objective</p> <p>Obtain utilities (preferences) for a generalizable set of health states experienced by older children and adolescents who receive therapy for chronic health conditions.</p> <p>Methods</p> <p>A health state clas...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | Health and Quality of Life Outcomes |
| Online Access: | http://www.hqlo.com/content/10/1/102 |
| _version_ | 1811286129409785856 |
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| author | Beusterien Kathleen M Yeung Jean-Ezra Pang Francis Brazier John |
| author_facet | Beusterien Kathleen M Yeung Jean-Ezra Pang Francis Brazier John |
| author_sort | Beusterien Kathleen M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>Obtain utilities (preferences) for a generalizable set of health states experienced by older children and adolescents who receive therapy for chronic health conditions.</p> <p>Methods</p> <p>A health state classification system, the Adolescent Health Utility Measure (AHUM), was developed based on generic health status measures and input from children with Hunter syndrome and their caregivers. The AHUM contains six dimensions with 4–7 severity levels: self-care, pain, mobility, strenuous activities, self-image, and health perceptions. Using the time trade off (TTO) approach, a UK population sample provided utilities for 62 of 16,800 AHUM states. A mixed effects model was used to estimate utilities for the AHUM states. The AHUM was applied to trial NCT00069641 of idursulfase for Hunter syndrome and its extension (NCT00630747).</p> <p>Results</p> <p>Observations (i.e., utilities) totaled 3,744 (12*312 participants), with between 43 to 60 for each health state except for the best and worst states which had 312 observations. The mean utilities for the best and worst AHUM states were 0.99 and 0.41, respectively. The random effects model was statistically significant (p < 0.0001; adjusted R2 = 0.361; RMSE = 0.194). When AHUM utilities were applied to the idursulfase trial, mean utilities in the idursulfase weekly and placebo groups improved +0.087 and +0.006, respectively, from baseline to week 53. In the extension, when all patients received idursulfase, the utilities in the treatment group remained stable and the placebo group improved +0.039.</p> <p>Discussion</p> <p>The AHUM health state classification system may be used in future research to enable calculation of quality-adjust life expectancy for applicable health conditions.</p> |
| first_indexed | 2024-04-13T02:55:06Z |
| format | Article |
| id | doaj.art-7aab5c5b504e4e3f8f00efcb570d6264 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-04-13T02:55:06Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-7aab5c5b504e4e3f8f00efcb570d62642022-12-22T03:05:41ZengBMCHealth and Quality of Life Outcomes1477-75252012-08-0110110210.1186/1477-7525-10-102Development of the multi-attribute Adolescent Health Utility Measure (AHUM)Beusterien Kathleen MYeung Jean-EzraPang FrancisBrazier John<p>Abstract</p> <p>Objective</p> <p>Obtain utilities (preferences) for a generalizable set of health states experienced by older children and adolescents who receive therapy for chronic health conditions.</p> <p>Methods</p> <p>A health state classification system, the Adolescent Health Utility Measure (AHUM), was developed based on generic health status measures and input from children with Hunter syndrome and their caregivers. The AHUM contains six dimensions with 4–7 severity levels: self-care, pain, mobility, strenuous activities, self-image, and health perceptions. Using the time trade off (TTO) approach, a UK population sample provided utilities for 62 of 16,800 AHUM states. A mixed effects model was used to estimate utilities for the AHUM states. The AHUM was applied to trial NCT00069641 of idursulfase for Hunter syndrome and its extension (NCT00630747).</p> <p>Results</p> <p>Observations (i.e., utilities) totaled 3,744 (12*312 participants), with between 43 to 60 for each health state except for the best and worst states which had 312 observations. The mean utilities for the best and worst AHUM states were 0.99 and 0.41, respectively. The random effects model was statistically significant (p < 0.0001; adjusted R2 = 0.361; RMSE = 0.194). When AHUM utilities were applied to the idursulfase trial, mean utilities in the idursulfase weekly and placebo groups improved +0.087 and +0.006, respectively, from baseline to week 53. In the extension, when all patients received idursulfase, the utilities in the treatment group remained stable and the placebo group improved +0.039.</p> <p>Discussion</p> <p>The AHUM health state classification system may be used in future research to enable calculation of quality-adjust life expectancy for applicable health conditions.</p>http://www.hqlo.com/content/10/1/102 |
| spellingShingle | Beusterien Kathleen M Yeung Jean-Ezra Pang Francis Brazier John Development of the multi-attribute Adolescent Health Utility Measure (AHUM) Health and Quality of Life Outcomes |
| title | Development of the multi-attribute Adolescent Health Utility Measure (AHUM) |
| title_full | Development of the multi-attribute Adolescent Health Utility Measure (AHUM) |
| title_fullStr | Development of the multi-attribute Adolescent Health Utility Measure (AHUM) |
| title_full_unstemmed | Development of the multi-attribute Adolescent Health Utility Measure (AHUM) |
| title_short | Development of the multi-attribute Adolescent Health Utility Measure (AHUM) |
| title_sort | development of the multi attribute adolescent health utility measure ahum |
| url | http://www.hqlo.com/content/10/1/102 |
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