The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease are unsatisfactory, making the search for new chemotherapeutic agents...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0144033 |
| _version_ | 1819108825158909952 |
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| author | Vânia Cristina Desoti Danielle Lazarin-Bidóia Fabianne Martins Ribeiro Solange Cardoso Martins Jean Henrique da Silva Rodrigues Tania Ueda-Nakamura Celso Vataru Nakamura Valdecir Farias Ximenes Sueli de Oliveira Silva |
| author_facet | Vânia Cristina Desoti Danielle Lazarin-Bidóia Fabianne Martins Ribeiro Solange Cardoso Martins Jean Henrique da Silva Rodrigues Tania Ueda-Nakamura Celso Vataru Nakamura Valdecir Farias Ximenes Sueli de Oliveira Silva |
| author_sort | Vânia Cristina Desoti |
| collection | DOAJ |
| description | Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease are unsatisfactory, making the search for new chemotherapeutic agents essential. Previous studies have reported various biological activities of naphthoquinones, such as the trypanocidal and antitumor activity of vitamin K3. The combination of this vitamin with vitamin C exerted better effects against various cancer cells than when used alone. These effects have been attributed to an increase in reactive oxygen species generation. In the present study, we evaluated the activity of vitamin K3 and vitamin C, alone and in combination, against T. cruzi. The vitamin K3 + vitamin C combination exerted synergistic effects against three forms of T. cruzi, leading to morphological, ultrastructural, and functional changes by producing reactive species, decreasing reduced thiol groups, altering the cell cycle, causing lipid peroxidation, and forming autophagic vacuoles. Our hypothesis is that the vitamin K3 + vitamin C combination induces oxidative imbalance in T. cruzi, probably started by a redox cycling process that leads to parasite cell death. |
| first_indexed | 2024-12-22T03:16:05Z |
| format | Article |
| id | doaj.art-7aab83bdcf664d30bc0accff43fdd804 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T03:16:05Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7aab83bdcf664d30bc0accff43fdd8042022-12-21T18:40:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014403310.1371/journal.pone.0144033The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.Vânia Cristina DesotiDanielle Lazarin-BidóiaFabianne Martins RibeiroSolange Cardoso MartinsJean Henrique da Silva RodriguesTania Ueda-NakamuraCelso Vataru NakamuraValdecir Farias XimenesSueli de Oliveira SilvaChagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease are unsatisfactory, making the search for new chemotherapeutic agents essential. Previous studies have reported various biological activities of naphthoquinones, such as the trypanocidal and antitumor activity of vitamin K3. The combination of this vitamin with vitamin C exerted better effects against various cancer cells than when used alone. These effects have been attributed to an increase in reactive oxygen species generation. In the present study, we evaluated the activity of vitamin K3 and vitamin C, alone and in combination, against T. cruzi. The vitamin K3 + vitamin C combination exerted synergistic effects against three forms of T. cruzi, leading to morphological, ultrastructural, and functional changes by producing reactive species, decreasing reduced thiol groups, altering the cell cycle, causing lipid peroxidation, and forming autophagic vacuoles. Our hypothesis is that the vitamin K3 + vitamin C combination induces oxidative imbalance in T. cruzi, probably started by a redox cycling process that leads to parasite cell death.https://doi.org/10.1371/journal.pone.0144033 |
| spellingShingle | Vânia Cristina Desoti Danielle Lazarin-Bidóia Fabianne Martins Ribeiro Solange Cardoso Martins Jean Henrique da Silva Rodrigues Tania Ueda-Nakamura Celso Vataru Nakamura Valdecir Farias Ximenes Sueli de Oliveira Silva The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process. PLoS ONE |
| title | The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process. |
| title_full | The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process. |
| title_fullStr | The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process. |
| title_full_unstemmed | The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process. |
| title_short | The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process. |
| title_sort | combination of vitamin k3 and vitamin c has synergic activity against forms of trypanosoma cruzi through a redox imbalance process |
| url | https://doi.org/10.1371/journal.pone.0144033 |
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