Engineered Livers for Infectious Diseases
Engineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell–derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X17301601 |
| _version_ | 1830343819593252864 |
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| author | Nil Gural Liliana Mancio-Silva Jiang He Sangeeta N. Bhatia |
| author_facet | Nil Gural Liliana Mancio-Silva Jiang He Sangeeta N. Bhatia |
| author_sort | Nil Gural |
| collection | DOAJ |
| description | Engineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell–derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases. Although improvement of existing models is always beneficial, and the addition of a robust immune component is a particular need, at present, considerable progress has been made using this combination of research platforms. We highlight advances in the study of hepatitis B and C viruses and malaria-causing Plasmodium falciparum and Plasmodium vivax parasites, and underscore the importance of pairing the most appropriate model system and readout modality with the particular experimental question at hand, without always requiring a platform that recapitulates human physiology in its entirety. |
| first_indexed | 2024-12-19T22:15:56Z |
| format | Article |
| id | doaj.art-7aad1d46622a4a739da3677dcc26d9bf |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-19T22:15:56Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-7aad1d46622a4a739da3677dcc26d9bf2022-12-21T20:03:46ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2018-01-015213114410.1016/j.jcmgh.2017.11.005Engineered Livers for Infectious DiseasesNil Gural0Liliana Mancio-Silva1Jiang He2Sangeeta N. Bhatia3Harvard-MIT Department of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, MassachusettsKoch Institute, Massachusetts Institute of Technology, Cambridge, MassachusettsKoch Institute, Massachusetts Institute of Technology, Cambridge, MassachusettsKoch Institute, Massachusetts Institute of Technology, Cambridge, MassachusettsEngineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell–derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases. Although improvement of existing models is always beneficial, and the addition of a robust immune component is a particular need, at present, considerable progress has been made using this combination of research platforms. We highlight advances in the study of hepatitis B and C viruses and malaria-causing Plasmodium falciparum and Plasmodium vivax parasites, and underscore the importance of pairing the most appropriate model system and readout modality with the particular experimental question at hand, without always requiring a platform that recapitulates human physiology in its entirety.http://www.sciencedirect.com/science/article/pii/S2352345X17301601LiverLiver Models3Din vitroin vivoHepatotropicPathogenHBVHCVMalariaFalciparumVivax |
| spellingShingle | Nil Gural Liliana Mancio-Silva Jiang He Sangeeta N. Bhatia Engineered Livers for Infectious Diseases Cellular and Molecular Gastroenterology and Hepatology Liver Liver Models 3D in vitro in vivo Hepatotropic Pathogen HBV HCV Malaria Falciparum Vivax |
| title | Engineered Livers for Infectious Diseases |
| title_full | Engineered Livers for Infectious Diseases |
| title_fullStr | Engineered Livers for Infectious Diseases |
| title_full_unstemmed | Engineered Livers for Infectious Diseases |
| title_short | Engineered Livers for Infectious Diseases |
| title_sort | engineered livers for infectious diseases |
| topic | Liver Liver Models 3D in vitro in vivo Hepatotropic Pathogen HBV HCV Malaria Falciparum Vivax |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X17301601 |
| work_keys_str_mv | AT nilgural engineeredliversforinfectiousdiseases AT lilianamanciosilva engineeredliversforinfectiousdiseases AT jianghe engineeredliversforinfectiousdiseases AT sangeetanbhatia engineeredliversforinfectiousdiseases |