Combination of Oligofructose and Metformin Alters the Gut Microbiota and Improves Metabolic Profiles, Contributing to the Potentiated Therapeutic Effects on Diet-Induced Obese Animals

Combination of Oligofructose and Metformin Alters the Gut Microbiota and Improves Metabolic Profiles, Contributing to the Potentiated Therapeutic Effects on Diet-Induced Obese Animals

Accumulating studies implicate that the metformin (MET)- and oligofructose (OFS)-altered gut microbiota may play roles in the improvement of type 2 diabetes mellitus (T2DM) and obesity. However, whether the combined administration of OFS and MET could effectively affect the gut microbiota and improv...

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Bibliographic Details
Main Authors: Qingzhong Li, Rui He, Fengmei Zhang, Jian Zhang, Shihai Lian, Hongxia Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Endocrinology
Subjects:
metformin
oligofructose
gut microbiota
obesity
T2DM
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00939/full

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