A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination

A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination

Summary: Immunoglobulin G (IgG) antibodies that activate Fc-mediated immune functions have been correlated with vaccine efficacy, but it is difficult to unravel the relative roles of multiple IgG and Fc receptor (FcR) features that have the capacity to influence IgG-FcR complex formation but vary on...

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Bibliographic Details
Main Authors: Melissa M. Lemke, Milla R. McLean, Christina Y. Lee, Ester Lopez, Emily R. Bozich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports Medicine
Subjects:
systems serology
Fc receptor
IgG
RV144
HIV
vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121002445

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