The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea

The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea

BackgroundFurosemide is a loop diuretic used to treat edema; however, it also targets the Na-K-Cl cotransporter-1 (NKCC1) in the inner ear. In very high doses, furosemide abolishes the endocochlear potential (EP). The aim of the study was to gain a deeper understanding of the temporal course of the...

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Bibliographic Details
Main Authors: Jesper Edvardsson Rasmussen, Patrik Lundström, Per Olof Eriksson, Helge Rask-Andersen, Wei Liu, Göran Laurell
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
furosemide (frusemide)
NKCC1 = Na+-K+-2Cl— cotransporter
type II fibrocyte
fetuin-A
PEDF
stria vascularis
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.842132/full

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