Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan
<p>Abstract</p> <p>Background</p> <p>Early diagnosis and effective treatment with an appropriate drug form the main components of the World Health Organization's strategy to reduce malaria related mortality. The few available drugs might be safeguarded if combined...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-09-01
|
| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/4/1/41 |
| _version_ | 1819028983051714560 |
|---|---|
| author | Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag |
| author_facet | Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag |
| author_sort | Ahmed Elderderi S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Early diagnosis and effective treatment with an appropriate drug form the main components of the World Health Organization's strategy to reduce malaria related mortality. The few available drugs might be safeguarded if combined with artesunate. The addition of artesunate to a standard antimalarial treatment substantially reduces treatment failure, recrudescence and gametocyte carriage.</p> <p>Methods</p> <p>During late 2004, the efficacy of artesunate (4 mg/kg. day, on days 0–2) plus sulfadoxine-pyrimethamine (25 mg/kg, on day 0) for the treatment of uncomplicated <it>Plasmodium falciparum </it>malaria was investigated in four sentinel areas in Sudan, with different malaria transmission (Damazin, Kassala, Kosti, and Malakal).</p> <p>Results</p> <p>Two hundreds and sixty-nine patients completed the 28-day follow-up. On day one, 60 (22.3%) patients were febrile and 15 (5.5%) patients were parasitaemic. On day three, all the patients were afebrile and aparasitaemic. While two patients (0.7%, Kassala) showed late Clinical and Parasitological Failures, the rest (99.3%) of the patients demonstrated Adequate Clinical and Parasitological Response. A gametocytaemia were detected during the follow-up in one patient (0.37%, Kassala). Adverse drug effects were detected in 32 (11.9%) patients</p> <p>Conclusion</p> <p>The study showed that AS plus SP is an effective, safe drug in the treatment of uncomplicated <it>P. falciparum </it>malaria in Sudan.</p> |
| first_indexed | 2024-12-21T06:07:01Z |
| format | Article |
| id | doaj.art-7ab0d60d8b7f42afb12cb0fe3b797676 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T06:07:01Z |
| publishDate | 2005-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-7ab0d60d8b7f42afb12cb0fe3b7976762022-12-21T19:13:37ZengBMCMalaria Journal1475-28752005-09-01414110.1186/1475-2875-4-41Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in SudanAhmed Elderderi SKhamiss Ammar HMohammed Mamoun MAbdelgadir TarigMalik Elfatih MElamin Sakina BAdam Ishag<p>Abstract</p> <p>Background</p> <p>Early diagnosis and effective treatment with an appropriate drug form the main components of the World Health Organization's strategy to reduce malaria related mortality. The few available drugs might be safeguarded if combined with artesunate. The addition of artesunate to a standard antimalarial treatment substantially reduces treatment failure, recrudescence and gametocyte carriage.</p> <p>Methods</p> <p>During late 2004, the efficacy of artesunate (4 mg/kg. day, on days 0–2) plus sulfadoxine-pyrimethamine (25 mg/kg, on day 0) for the treatment of uncomplicated <it>Plasmodium falciparum </it>malaria was investigated in four sentinel areas in Sudan, with different malaria transmission (Damazin, Kassala, Kosti, and Malakal).</p> <p>Results</p> <p>Two hundreds and sixty-nine patients completed the 28-day follow-up. On day one, 60 (22.3%) patients were febrile and 15 (5.5%) patients were parasitaemic. On day three, all the patients were afebrile and aparasitaemic. While two patients (0.7%, Kassala) showed late Clinical and Parasitological Failures, the rest (99.3%) of the patients demonstrated Adequate Clinical and Parasitological Response. A gametocytaemia were detected during the follow-up in one patient (0.37%, Kassala). Adverse drug effects were detected in 32 (11.9%) patients</p> <p>Conclusion</p> <p>The study showed that AS plus SP is an effective, safe drug in the treatment of uncomplicated <it>P. falciparum </it>malaria in Sudan.</p>http://www.malariajournal.com/content/4/1/41 |
| spellingShingle | Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan Malaria Journal |
| title | Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
| title_full | Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
| title_fullStr | Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
| title_full_unstemmed | Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
| title_short | Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
| title_sort | artesunate plus sulfadoxine pyrimethamine for treatment of uncomplicated plasmodium falciparum malaria in sudan |
| url | http://www.malariajournal.com/content/4/1/41 |
| work_keys_str_mv | AT ahmedelderderis artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan AT khamissammarh artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan AT mohammedmamounm artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan AT abdelgadirtarig artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan AT malikelfatihm artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan AT elaminsakinab artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan AT adamishag artesunateplussulfadoxinepyrimethaminefortreatmentofuncomplicatedplasmodiumfalciparummalariainsudan |