Sialidase facilitates Porphyromonas gingivalis immune evasion by reducing M1 polarization, antigen presentation, and phagocytosis of infected macrophages

Sialidase facilitates Porphyromonas gingivalis immune evasion by reducing M1 polarization, antigen presentation, and phagocytosis of infected macrophages

BackgroundPorphyromonas gingivalis (P. gingivalis), a major pathogen of periodontitis, can evade host immune defenses. Previously, we found that P. gingivalis W83 sialidase gene mutant strain (ΔPG0352) was more easily cleared by macrophages. The aims of this study were to investigate the effects of...

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Bibliographic Details
Main Authors: Xiaomiao Fan, Shaowen Zheng, Chen Chen, Li Lin, Hongyan Wang, Yuqin Shen, Yaping Pan, Chen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
periodontitis
Porphyromonas gingivalis
sialidase
macrophage
polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1173899/full

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