Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(<i>E</i>)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs

Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(<i>E</i>)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs

A series of hitherto unknown (1,4-disubstituted-1,2,3-triazol)-(<i>E</i>)-2-methyl-but-2-enyl nucleosides phosphonate prodrugs bearing 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as the key synthetic step. All novel compou...

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Bibliographic Details
Main Authors: Tuniyazi Abuduaini, Vincent Roy, Julien Marlet, Catherine Gaudy-Graffin, Denys Brand, Cécile Baronti, Franck Touret, Bruno Coutard, Tamara R. McBrayer, Raymond F. Schinazi, Luigi A. Agrofoglio
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
nucleosides
olefin cross metathesis
ultrasound
copper-catalyzed azide-alkyne cycloaddition (CuAAC)
antiviral properties
HBV
Online Access:https://www.mdpi.com/1420-3049/26/5/1493

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