Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors
Background & Objective: Selenium nanoparticles (Se -NPs) and selenium nanocomposites (Se -NCs) have different biological effects. Therefore, the present study aimed to compare the effects of selenium nanoparticles and selenium nanocomposites (Se –NCs) on anxiety, food intake, and brain histology...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2021-09-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-2473-en.pdf |
| _version_ | 1797679565177356288 |
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| author | Mohammad reza Hajinezhad AliReza Samzadeh Kermani |
| author_facet | Mohammad reza Hajinezhad AliReza Samzadeh Kermani |
| author_sort | Mohammad reza Hajinezhad |
| collection | DOAJ |
| description | Background & Objective: Selenium nanoparticles (Se -NPs) and selenium nanocomposites (Se -NCs) have different biological effects. Therefore, the present study aimed to compare the effects of selenium nanoparticles and selenium nanocomposites (Se –NCs) on anxiety, food intake, and brain histology of rats.
Materials & Methods: Thirty-two male adult Wistar rats were randomly and equally divided into four groups. The control group received saline, the Selenium powder group received 1 mg/kg /day selenium powder orally for 21 days, and the selenium nanoparticle group received three weeks of oral gavage of Se –NPs. The selenium nanocomposites group received three weeks of oral gavage of nanocomposites. Finally, cumulative food consumption and anxiety-like behaviors were assessed, and, after that, rats were bled and sacrificed for further biochemical and histopathological investigations.
Results: Oral administration of Se powder at a dose of 1 mg/kg /day for 21 days had no significant effect on the brain superoxide dismutase (SOD), catalase (CAT) activities. There was also no significant change in the levels of brain glutathione concentration (GSH), brain MDA, and behavioral parameters. Selenium nanoparticles also showed no significant alterations in brain biochemical parameters, behavioral effects, and brain histology. The oral administration of Selenium nanocomposites significantly increased brain superoxide dismutase, catalase, and reduced glutathione content and had positive effects on behavioral parameters.
Conclusion: The present study showed that Se -NCs have behavioral effects and could induce significant biochemical changes in brain oxidative status. |
| first_indexed | 2024-03-11T23:16:37Z |
| format | Article |
| id | doaj.art-7ab1b92d6cc7423d9028e7a43f42f47d |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:16:37Z |
| publishDate | 2021-09-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-7ab1b92d6cc7423d9028e7a43f42f47d2023-09-20T21:28:51ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232021-09-0111339393950Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like BehaviorsMohammad reza Hajinezhad0AliReza Samzadeh Kermani1 Department of Basic Sciences, Faculty of Veterinary , University of Zabol , Zabol, Iran Department of Chemistry, Faculty of Basic Science, University of Zabol, Zabol, Iran Background & Objective: Selenium nanoparticles (Se -NPs) and selenium nanocomposites (Se -NCs) have different biological effects. Therefore, the present study aimed to compare the effects of selenium nanoparticles and selenium nanocomposites (Se –NCs) on anxiety, food intake, and brain histology of rats. Materials & Methods: Thirty-two male adult Wistar rats were randomly and equally divided into four groups. The control group received saline, the Selenium powder group received 1 mg/kg /day selenium powder orally for 21 days, and the selenium nanoparticle group received three weeks of oral gavage of Se –NPs. The selenium nanocomposites group received three weeks of oral gavage of nanocomposites. Finally, cumulative food consumption and anxiety-like behaviors were assessed, and, after that, rats were bled and sacrificed for further biochemical and histopathological investigations. Results: Oral administration of Se powder at a dose of 1 mg/kg /day for 21 days had no significant effect on the brain superoxide dismutase (SOD), catalase (CAT) activities. There was also no significant change in the levels of brain glutathione concentration (GSH), brain MDA, and behavioral parameters. Selenium nanoparticles also showed no significant alterations in brain biochemical parameters, behavioral effects, and brain histology. The oral administration of Selenium nanocomposites significantly increased brain superoxide dismutase, catalase, and reduced glutathione content and had positive effects on behavioral parameters. Conclusion: The present study showed that Se -NCs have behavioral effects and could induce significant biochemical changes in brain oxidative status.http://jabs.fums.ac.ir/article-1-2473-en.pdfnanoparticlesseleniumbehaviorratoxidative stress |
| spellingShingle | Mohammad reza Hajinezhad AliReza Samzadeh Kermani Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors Journal of Advanced Biomedical Sciences nanoparticles selenium behavior rat oxidative stress |
| title | Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors |
| title_full | Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors |
| title_fullStr | Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors |
| title_full_unstemmed | Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors |
| title_short | Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors |
| title_sort | comparing the effects of selenium nanoparticles and selenium nanocomposites on food intake and anxiety like behaviors |
| topic | nanoparticles selenium behavior rat oxidative stress |
| url | http://jabs.fums.ac.ir/article-1-2473-en.pdf |
| work_keys_str_mv | AT mohammadrezahajinezhad comparingtheeffectsofseleniumnanoparticlesandseleniumnanocompositesonfoodintakeandanxietylikebehaviors AT alirezasamzadehkermani comparingtheeffectsofseleniumnanoparticlesandseleniumnanocompositesonfoodintakeandanxietylikebehaviors |