The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China
Abstract Background The clinical significance of protein tyrosine phosphatase nonreceptor type 11 mutation (PTPN11mut) in acute myeloid leukemia (AML) is underestimated. Methods We collected the data of AML patients with mutated PTPN11 and wild‐type PTPN11 (PTPN11wt) treated at our hospital and anal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6669 |
| _version_ | 1797387125045329920 |
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| author | Jinjun Yang Lei Zhao Yu Wu Ting Niu Yuping Gong Xinchuan Chen Xiaoou Huang Jiazhuo Liu Yang Dai Hongbing Ma |
| author_facet | Jinjun Yang Lei Zhao Yu Wu Ting Niu Yuping Gong Xinchuan Chen Xiaoou Huang Jiazhuo Liu Yang Dai Hongbing Ma |
| author_sort | Jinjun Yang |
| collection | DOAJ |
| description | Abstract Background The clinical significance of protein tyrosine phosphatase nonreceptor type 11 mutation (PTPN11mut) in acute myeloid leukemia (AML) is underestimated. Methods We collected the data of AML patients with mutated PTPN11 and wild‐type PTPN11 (PTPN11wt) treated at our hospital and analyzed their clinical characteristics and prognosis. Results Fifty‐nine PTPN11mut and 124 PTPN11wt AML patients were included. PTPN11mut was more common in myelomonocytic and monocytic leukemia, and was more likely to co‐mutate with KRAS, KMT2C, NRAS, U2AF1, NOTCH1, IKZF1, and USH2A mutations than PTPN11wt. The overall survival for AML patients with PTPN11mut was significantly shorter than that for those with PTPN11wt (p = 0.03). The negative impact of PTPN11mut on overall survival was pronounced in the “favorable” and “intermediate” groups of ELN2017 risk stratification, as well as in the wild‐type NPM1 group (p = 0.01, p = 0.01, and p = 0.04). Conclusion PTPN11mut is associated with distinct clinical and molecular characteristics, and adverse prognosis in AML patients. |
| first_indexed | 2024-03-08T22:19:21Z |
| format | Article |
| id | doaj.art-7ab46c18738b46b6953282996115ea69 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-08T22:19:21Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-7ab46c18738b46b6953282996115ea692023-12-18T14:43:07ZengWileyCancer Medicine2045-76342023-12-011223211112111710.1002/cam4.6669The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in ChinaJinjun Yang0Lei Zhao1Yu Wu2Ting Niu3Yuping Gong4Xinchuan Chen5Xiaoou Huang6Jiazhuo Liu7Yang Dai8Hongbing Ma9Department of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaDepartment of Hematology and Institute of Hematology, West China Hospital Sichuan University Chengdu ChinaAbstract Background The clinical significance of protein tyrosine phosphatase nonreceptor type 11 mutation (PTPN11mut) in acute myeloid leukemia (AML) is underestimated. Methods We collected the data of AML patients with mutated PTPN11 and wild‐type PTPN11 (PTPN11wt) treated at our hospital and analyzed their clinical characteristics and prognosis. Results Fifty‐nine PTPN11mut and 124 PTPN11wt AML patients were included. PTPN11mut was more common in myelomonocytic and monocytic leukemia, and was more likely to co‐mutate with KRAS, KMT2C, NRAS, U2AF1, NOTCH1, IKZF1, and USH2A mutations than PTPN11wt. The overall survival for AML patients with PTPN11mut was significantly shorter than that for those with PTPN11wt (p = 0.03). The negative impact of PTPN11mut on overall survival was pronounced in the “favorable” and “intermediate” groups of ELN2017 risk stratification, as well as in the wild‐type NPM1 group (p = 0.01, p = 0.01, and p = 0.04). Conclusion PTPN11mut is associated with distinct clinical and molecular characteristics, and adverse prognosis in AML patients.https://doi.org/10.1002/cam4.6669acute myeloid leukemiaevent‐free survivaloverall survivalPTPN11 |
| spellingShingle | Jinjun Yang Lei Zhao Yu Wu Ting Niu Yuping Gong Xinchuan Chen Xiaoou Huang Jiazhuo Liu Yang Dai Hongbing Ma The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China Cancer Medicine acute myeloid leukemia event‐free survival overall survival PTPN11 |
| title | The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China |
| title_full | The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China |
| title_fullStr | The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China |
| title_full_unstemmed | The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China |
| title_short | The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China |
| title_sort | clinical features and prognostic implications of ptpn11 mutation in adult patients with acute myeloid leukemia in china |
| topic | acute myeloid leukemia event‐free survival overall survival PTPN11 |
| url | https://doi.org/10.1002/cam4.6669 |
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