Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin
BackgroundInfantile colic (IC) is a condition characterized by extensive crying which affects about 20% of all infants during their first months of life. Most pediatricians diagnose IC only based on their clinical experience.AimInvestigating if a measurement of fecal calprotectin can support the dia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.978545/full |
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| author | Henning Sommermeyer Malgorzata Bernatek Marcin Pszczola Hanna Krauss Jacek Piatek |
| author_facet | Henning Sommermeyer Malgorzata Bernatek Marcin Pszczola Hanna Krauss Jacek Piatek |
| author_sort | Henning Sommermeyer |
| collection | DOAJ |
| description | BackgroundInfantile colic (IC) is a condition characterized by extensive crying which affects about 20% of all infants during their first months of life. Most pediatricians diagnose IC only based on their clinical experience.AimInvestigating if a measurement of fecal calprotectin can support the diagnosis of IC.MethodsThe crying behavior of newborns was assessed using the Wessel's criteria. Fecal calprotectin levels were measured in non-colicky and colicky babies using a standard test that can be used at the time and place of patient care (point of care (PoC) measurement).ResultsColicky babies were found to have significantly elevated fecal calprotectin levels. Calprotectin levels were not influenced by gender, type of feeding, gestation age or birth weight. However, significantly elevated fecal calprotectin levels were found in cesarean section born babies. Fecal calprotectin ≥100 μg/g correlated with a colicky status of an infant while those <100 μg/g indicated a non-colicky status the error margin was 11.2 and 13.2%, respectively. Combining data of fecal calprotectin with information about the type of delivery made it possible to determine the colicky status in vaginally-born infants with fecal calprotectin ≥100 μg/g with an accuracy of 97.8%. As elevated fecal calprotectin levels in cesarean-born infants can be caused by IC, but also by the disturbed gut microbiota commonly found in these babies, the accuracy of diagnosing the colicky status of a cesarean-born infant with calprotectin levels ≥100 μg/g was less accurate (accuracy rate of 76.5%).ConclusionData from the study suggest that measuring fecal calprotectin should be considered by pediatricians to support the diagnosis of IC.The study was registered at ClinicalTrials.gov under NCT04666324. |
| first_indexed | 2024-04-11T11:15:05Z |
| format | Article |
| id | doaj.art-7ab67ac6891b4731af820d4535fd2bdb |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T11:15:05Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7ab67ac6891b4731af820d4535fd2bdb2022-12-22T04:27:16ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-09-011010.3389/fped.2022.978545978545Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectinHenning Sommermeyer0Malgorzata Bernatek1Marcin Pszczola2Hanna Krauss3Jacek Piatek4Department of Health Sciences, Calisia University, Kalisz, PolandDepartment of Health Sciences, Calisia University, Kalisz, PolandDepartment of Genetic and Animal Breeding, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Poznan, PolandDepartment of Health Sciences, Calisia University, Kalisz, PolandDepartment of Health Sciences, Calisia University, Kalisz, PolandBackgroundInfantile colic (IC) is a condition characterized by extensive crying which affects about 20% of all infants during their first months of life. Most pediatricians diagnose IC only based on their clinical experience.AimInvestigating if a measurement of fecal calprotectin can support the diagnosis of IC.MethodsThe crying behavior of newborns was assessed using the Wessel's criteria. Fecal calprotectin levels were measured in non-colicky and colicky babies using a standard test that can be used at the time and place of patient care (point of care (PoC) measurement).ResultsColicky babies were found to have significantly elevated fecal calprotectin levels. Calprotectin levels were not influenced by gender, type of feeding, gestation age or birth weight. However, significantly elevated fecal calprotectin levels were found in cesarean section born babies. Fecal calprotectin ≥100 μg/g correlated with a colicky status of an infant while those <100 μg/g indicated a non-colicky status the error margin was 11.2 and 13.2%, respectively. Combining data of fecal calprotectin with information about the type of delivery made it possible to determine the colicky status in vaginally-born infants with fecal calprotectin ≥100 μg/g with an accuracy of 97.8%. As elevated fecal calprotectin levels in cesarean-born infants can be caused by IC, but also by the disturbed gut microbiota commonly found in these babies, the accuracy of diagnosing the colicky status of a cesarean-born infant with calprotectin levels ≥100 μg/g was less accurate (accuracy rate of 76.5%).ConclusionData from the study suggest that measuring fecal calprotectin should be considered by pediatricians to support the diagnosis of IC.The study was registered at ClinicalTrials.gov under NCT04666324.https://www.frontiersin.org/articles/10.3389/fped.2022.978545/fullcolicky babiesgut microbiotacesarean sectionfecal calprotectin (FC)gut inflammationinfantile colic |
| spellingShingle | Henning Sommermeyer Malgorzata Bernatek Marcin Pszczola Hanna Krauss Jacek Piatek Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin Frontiers in Pediatrics colicky babies gut microbiota cesarean section fecal calprotectin (FC) gut inflammation infantile colic |
| title | Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin |
| title_full | Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin |
| title_fullStr | Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin |
| title_full_unstemmed | Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin |
| title_short | Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin |
| title_sort | supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin |
| topic | colicky babies gut microbiota cesarean section fecal calprotectin (FC) gut inflammation infantile colic |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.978545/full |
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