Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy
To maintain the body’s regular immune system, CD4+ T cell homeostasis is crucial, particularly T helper (Th1, Th17) cells and T regulatory (Treg) cells. Abnormally differentiated peripheral CD4+ T cells are responsible for the occurrence and development of numerous diseases, including autoimmune dis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221530/full |
| _version_ | 1827896002122612736 |
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| author | Tong Liu Tong Liu Shaohua Ren Shaohua Ren Chenglu Sun Chenglu Sun Pengyu Zhao Pengyu Zhao Hao Wang Hao Wang |
| author_facet | Tong Liu Tong Liu Shaohua Ren Shaohua Ren Chenglu Sun Chenglu Sun Pengyu Zhao Pengyu Zhao Hao Wang Hao Wang |
| author_sort | Tong Liu |
| collection | DOAJ |
| description | To maintain the body’s regular immune system, CD4+ T cell homeostasis is crucial, particularly T helper (Th1, Th17) cells and T regulatory (Treg) cells. Abnormally differentiated peripheral CD4+ T cells are responsible for the occurrence and development of numerous diseases, including autoimmune diseases, transplantation rejection, and irritability. Searching for an effective interventional approach to control this abnormal differentiation is therefore especially important. As immunometabolism progressed, the inherent metabolic factors underlying the immune cell differentiation have gradually come to light. Mounting number of studies have revealed that glutaminolysis plays an indelible role in the differentiation of CD4+ T cells. Besides, alterations in the glutaminolysis can also lead to changes in the fate of peripheral CD4+ T cells. All of this indicate that the glutaminolysis pathway has excellent potential for interventional regulation of CD4+ T cells differentiation. Here, we summarized the process by which glutaminolysis regulates the fate of CD4+ T cells during differentiation and further investigated how to reshape abnormal CD4+ T cell differentiation by targeting glutaminolysis. |
| first_indexed | 2024-03-12T22:29:38Z |
| format | Article |
| id | doaj.art-7ab67dccfd9e4e9eb102b83a83e4e819 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T22:29:38Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7ab67dccfd9e4e9eb102b83a83e4e8192023-07-21T18:09:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12215301221530Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategyTong Liu0Tong Liu1Shaohua Ren2Shaohua Ren3Chenglu Sun4Chenglu Sun5Pengyu Zhao6Pengyu Zhao7Hao Wang8Hao Wang9Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin General Surgery Institute, Tianjin, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin General Surgery Institute, Tianjin, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin General Surgery Institute, Tianjin, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin General Surgery Institute, Tianjin, ChinaDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin General Surgery Institute, Tianjin, ChinaTo maintain the body’s regular immune system, CD4+ T cell homeostasis is crucial, particularly T helper (Th1, Th17) cells and T regulatory (Treg) cells. Abnormally differentiated peripheral CD4+ T cells are responsible for the occurrence and development of numerous diseases, including autoimmune diseases, transplantation rejection, and irritability. Searching for an effective interventional approach to control this abnormal differentiation is therefore especially important. As immunometabolism progressed, the inherent metabolic factors underlying the immune cell differentiation have gradually come to light. Mounting number of studies have revealed that glutaminolysis plays an indelible role in the differentiation of CD4+ T cells. Besides, alterations in the glutaminolysis can also lead to changes in the fate of peripheral CD4+ T cells. All of this indicate that the glutaminolysis pathway has excellent potential for interventional regulation of CD4+ T cells differentiation. Here, we summarized the process by which glutaminolysis regulates the fate of CD4+ T cells during differentiation and further investigated how to reshape abnormal CD4+ T cell differentiation by targeting glutaminolysis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221530/fullCD4 + T cellsglutaminolysisT cell differentiationimmunometabolismintervention strategy |
| spellingShingle | Tong Liu Tong Liu Shaohua Ren Shaohua Ren Chenglu Sun Chenglu Sun Pengyu Zhao Pengyu Zhao Hao Wang Hao Wang Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy Frontiers in Immunology CD4 + T cells glutaminolysis T cell differentiation immunometabolism intervention strategy |
| title | Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy |
| title_full | Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy |
| title_fullStr | Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy |
| title_full_unstemmed | Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy |
| title_short | Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy |
| title_sort | glutaminolysis and peripheral cd4 t cell differentiation from mechanism to intervention strategy |
| topic | CD4 + T cells glutaminolysis T cell differentiation immunometabolism intervention strategy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221530/full |
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