Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent
The essential oil obtained by the fresh fruit of <i>Citrus bergamia</i> Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essenti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2597 |
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| author | Laura Rombolà Damiana Scuteri Chizuko Watanabe Shinobu Sakurada Kengo Hamamura Tsukasa Sakurada Paolo Tonin Maria Tiziana Corasaniti Giacinto Bagetta Luigi Antonio Morrone |
| author_facet | Laura Rombolà Damiana Scuteri Chizuko Watanabe Shinobu Sakurada Kengo Hamamura Tsukasa Sakurada Paolo Tonin Maria Tiziana Corasaniti Giacinto Bagetta Luigi Antonio Morrone |
| author_sort | Laura Rombolà |
| collection | DOAJ |
| description | The essential oil obtained by the fresh fruit of <i>Citrus bergamia</i> Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests. |
| first_indexed | 2024-03-10T20:35:14Z |
| format | Article |
| id | doaj.art-7abe72e4a61c40f6bc753bb60b0c6919 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:35:14Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7abe72e4a61c40f6bc753bb60b0c69192023-11-19T21:04:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217259710.3390/ijms21072597Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in RodentLaura Rombolà0Damiana Scuteri1Chizuko Watanabe2Shinobu Sakurada3Kengo Hamamura4Tsukasa Sakurada5Paolo Tonin6Maria Tiziana Corasaniti7Giacinto Bagetta8Luigi Antonio Morrone9Preclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, ItalyPreclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, ItalyDepartment of Physiology and Anatomy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDepartment of Physiology and Anatomy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDaiichi College of Pharmaceutical Sciences—First Department of Pharmacology Fukuoka, Fukuoka 815-8511, JapanDaiichi College of Pharmaceutical Sciences—First Department of Pharmacology Fukuoka, Fukuoka 815-8511, JapanRegional Center for Serious Brain Injuries, S. Anna Institute, 88900 Crotone, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyPreclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, ItalyPreclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, ItalyThe essential oil obtained by the fresh fruit of <i>Citrus bergamia</i> Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.https://www.mdpi.com/1422-0067/21/7/2597aromatherapybergamot essential oilserotonin neurotransmissionanxiety and motor behavioral tests |
| spellingShingle | Laura Rombolà Damiana Scuteri Chizuko Watanabe Shinobu Sakurada Kengo Hamamura Tsukasa Sakurada Paolo Tonin Maria Tiziana Corasaniti Giacinto Bagetta Luigi Antonio Morrone Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent International Journal of Molecular Sciences aromatherapy bergamot essential oil serotonin neurotransmission anxiety and motor behavioral tests |
| title | Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent |
| title_full | Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent |
| title_fullStr | Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent |
| title_full_unstemmed | Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent |
| title_short | Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent |
| title_sort | role of 5 ht1a receptor in the anxiolytic relaxant effects of bergamot essential oil in rodent |
| topic | aromatherapy bergamot essential oil serotonin neurotransmission anxiety and motor behavioral tests |
| url | https://www.mdpi.com/1422-0067/21/7/2597 |
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