Dynamical Systems: An Effective Way in Nanotoxicology Study
Bio-safety assessment of nanomaterials and related products is in great need for models to be developed, that enable to analyze nanotoxicity in intricate biological systems. However, up to date, there have been few investigations on feasible approaches to assess safety and toxicity of nanoscale prod...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-03-01
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| Series: | Journal of Algorithms & Computational Technology |
| Online Access: | https://doi.org/10.1260/1748-3018.5.1.79 |
| Summary: | Bio-safety assessment of nanomaterials and related products is in great need for models to be developed, that enable to analyze nanotoxicity in intricate biological systems. However, up to date, there have been few investigations on feasible approaches to assess safety and toxicity of nanoscale products reported. In this paper, a dynamical system model has been proposed and a new approach for analyzing homeostasis and evaluating potential systemic toxicity in a living biological system has been developed for nanotoxicology study. Based on the model and approach, the toxicity of 30 nm-sized Fe 3 O 4 and TiO 2 nanoparticles were investigated and explained. Experiment results verify feasibility and effectiveness of the dynamical system we proposed. It also can be adapted to a wider range of applications such as general toxicology study, pharmacokinetics, diagnosis etc. |
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| ISSN: | 1748-3018 1748-3026 |