Psoriasis as a risk factor of pulmonary embolism - case report
Introduction. Deep vein thrombosis and pulmonary embolism, known as venous thromboembolism, constitute a major global burden of disease. Both entities share the same risk factors. Psoriasis is a common, chronic skin disease. It also presents multisystemic inflammation, mainly affecting skin and join...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2019-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501900077M.pdf |
| _version_ | 1811344635240382464 |
|---|---|
| author | Milić Rade Šarac Sanja Lazović-Popović Biljana Dinić Miroslav |
| author_facet | Milić Rade Šarac Sanja Lazović-Popović Biljana Dinić Miroslav |
| author_sort | Milić Rade |
| collection | DOAJ |
| description | Introduction. Deep vein thrombosis and pulmonary embolism, known as venous thromboembolism, constitute a major global burden of disease. Both entities share the same risk factors. Psoriasis is a common, chronic skin disease. It also presents multisystemic inflammation, mainly affecting skin and joints, but it is also associated with the significant cardiovascular and metabolic states and comorbidities, on the so-called “psoriatic march”. Case report. We presented a 78-year-old female patient, with psoriasis associated with pulmonary embolism which is accidentally discovered. We did not find any other predisposing factor of this disease (primary or secondary thrombophilia), except hyperhomocysteinemia. The patient was treated with low molecular weight heparin (enoxaparin), followed by the administration of an oral vitamin K antagonist (warfarin sodium) in the weight adjusted regimens. Additionally, we recommended vitamin B complex, including folate. Supposed link between hyperhomocysteinemia and psoriasis was the decreased serum folate level as the result of increased vitamin utilization in the skin because of increased DNA synthesis. Conclusion. The reported case reflects existing literary knowledge about the increased risk of VTE and arterial thromboembolic events in the psoriatic patients. The highest risk appears in the patients with a severe disease and may be a consequence of systemic inflammation and hyperhomocysteinemia. |
| first_indexed | 2024-04-13T19:51:06Z |
| format | Article |
| id | doaj.art-7ac52d7b74f4403ab9ce4f0711c1a072 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-13T19:51:06Z |
| publishDate | 2019-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-7ac52d7b74f4403ab9ce4f0711c1a0722022-12-22T02:32:33ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202019-01-0176996897210.2298/VSP170717077M0042-84501900077MPsoriasis as a risk factor of pulmonary embolism - case reportMilić Rade0Šarac Sanja1Lazović-Popović Biljana2Dinić Miroslav3Military Medical Academy, Clinic for Pulmonology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, Clinic for Pulmonology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaUniversity Clinical Hospital Center “Zemun”, Belgrade, SerbiaClinic for Dermatology and Venereology, Belgrade, SerbiaIntroduction. Deep vein thrombosis and pulmonary embolism, known as venous thromboembolism, constitute a major global burden of disease. Both entities share the same risk factors. Psoriasis is a common, chronic skin disease. It also presents multisystemic inflammation, mainly affecting skin and joints, but it is also associated with the significant cardiovascular and metabolic states and comorbidities, on the so-called “psoriatic march”. Case report. We presented a 78-year-old female patient, with psoriasis associated with pulmonary embolism which is accidentally discovered. We did not find any other predisposing factor of this disease (primary or secondary thrombophilia), except hyperhomocysteinemia. The patient was treated with low molecular weight heparin (enoxaparin), followed by the administration of an oral vitamin K antagonist (warfarin sodium) in the weight adjusted regimens. Additionally, we recommended vitamin B complex, including folate. Supposed link between hyperhomocysteinemia and psoriasis was the decreased serum folate level as the result of increased vitamin utilization in the skin because of increased DNA synthesis. Conclusion. The reported case reflects existing literary knowledge about the increased risk of VTE and arterial thromboembolic events in the psoriatic patients. The highest risk appears in the patients with a severe disease and may be a consequence of systemic inflammation and hyperhomocysteinemia.http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501900077M.pdfvenous thrombosispulmonary embolismpsoriasisrisk factorscomorbidityhomocysteine |
| spellingShingle | Milić Rade Šarac Sanja Lazović-Popović Biljana Dinić Miroslav Psoriasis as a risk factor of pulmonary embolism - case report Vojnosanitetski Pregled venous thrombosis pulmonary embolism psoriasis risk factors comorbidity homocysteine |
| title | Psoriasis as a risk factor of pulmonary embolism - case report |
| title_full | Psoriasis as a risk factor of pulmonary embolism - case report |
| title_fullStr | Psoriasis as a risk factor of pulmonary embolism - case report |
| title_full_unstemmed | Psoriasis as a risk factor of pulmonary embolism - case report |
| title_short | Psoriasis as a risk factor of pulmonary embolism - case report |
| title_sort | psoriasis as a risk factor of pulmonary embolism case report |
| topic | venous thrombosis pulmonary embolism psoriasis risk factors comorbidity homocysteine |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501900077M.pdf |
| work_keys_str_mv | AT milicrade psoriasisasariskfactorofpulmonaryembolismcasereport AT saracsanja psoriasisasariskfactorofpulmonaryembolismcasereport AT lazovicpopovicbiljana psoriasisasariskfactorofpulmonaryembolismcasereport AT dinicmiroslav psoriasisasariskfactorofpulmonaryembolismcasereport |