Antigen-based immunotherapy for autoimmune disease: current status
Darren Lowell Hirsch, Punita Ponda Division of Allergy and Immunology, North Shore-Long Island Jewish Health System/Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, USA Abstract: Autoimmune diseases are common chronic disorders that not only have a major impact on the quality of life...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-12-01
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| Series: | ImmunoTargets and Therapy |
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| Online Access: | https://www.dovepress.com/antigen-based-immunotherapy-for-autoimmune-disease-current-status-peer-reviewed-article-ITT |
| _version_ | 1819087130334330880 |
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| author | Hirsch DL Ponda P |
| author_facet | Hirsch DL Ponda P |
| author_sort | Hirsch DL |
| collection | DOAJ |
| description | Darren Lowell Hirsch, Punita Ponda Division of Allergy and Immunology, North Shore-Long Island Jewish Health System/Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, USA Abstract: Autoimmune diseases are common chronic disorders that not only have a major impact on the quality of life but are also potentially life-threatening. Treatment modalities that are currently favored have conferred significant clinical benefits, but they may have considerable side effects. An optimal treatment strategy for autoimmune disease would specifically target disease-associated antigens and limit systemic side effects. Similar to allergen-specific immunotherapy for allergic rhinitis, antigen-specific immunotherapy for autoimmune disease aims to induce immune deviation and promote tolerance to specific antigens. In this review, we present the current status of studies and clinical trials in both human and animal hosts that use antigen-based immunotherapy for autoimmune disease. Keywords: autoimmune disease, immunotherapy, antigen, diabetes, rheumatoid arthritis, multiple sclerosis |
| first_indexed | 2024-12-21T21:31:15Z |
| format | Article |
| id | doaj.art-7ac5caec9bc040dc8db6893a425c9ae7 |
| institution | Directory Open Access Journal |
| issn | 2253-1556 |
| language | English |
| last_indexed | 2024-12-21T21:31:15Z |
| publishDate | 2014-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | ImmunoTargets and Therapy |
| spelling | doaj.art-7ac5caec9bc040dc8db6893a425c9ae72022-12-21T18:49:37ZengDove Medical PressImmunoTargets and Therapy2253-15562014-12-012015Issue 111119602Antigen-based immunotherapy for autoimmune disease: current statusHirsch DLPonda PDarren Lowell Hirsch, Punita Ponda Division of Allergy and Immunology, North Shore-Long Island Jewish Health System/Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, USA Abstract: Autoimmune diseases are common chronic disorders that not only have a major impact on the quality of life but are also potentially life-threatening. Treatment modalities that are currently favored have conferred significant clinical benefits, but they may have considerable side effects. An optimal treatment strategy for autoimmune disease would specifically target disease-associated antigens and limit systemic side effects. Similar to allergen-specific immunotherapy for allergic rhinitis, antigen-specific immunotherapy for autoimmune disease aims to induce immune deviation and promote tolerance to specific antigens. In this review, we present the current status of studies and clinical trials in both human and animal hosts that use antigen-based immunotherapy for autoimmune disease. Keywords: autoimmune disease, immunotherapy, antigen, diabetes, rheumatoid arthritis, multiple sclerosishttps://www.dovepress.com/antigen-based-immunotherapy-for-autoimmune-disease-current-status-peer-reviewed-article-ITTautoimmune diseaseimmunotherapyantigendiabetesrheumatoid arthritismultiple sclerosis |
| spellingShingle | Hirsch DL Ponda P Antigen-based immunotherapy for autoimmune disease: current status ImmunoTargets and Therapy autoimmune disease immunotherapy antigen diabetes rheumatoid arthritis multiple sclerosis |
| title | Antigen-based immunotherapy for autoimmune disease: current status |
| title_full | Antigen-based immunotherapy for autoimmune disease: current status |
| title_fullStr | Antigen-based immunotherapy for autoimmune disease: current status |
| title_full_unstemmed | Antigen-based immunotherapy for autoimmune disease: current status |
| title_short | Antigen-based immunotherapy for autoimmune disease: current status |
| title_sort | antigen based immunotherapy for autoimmune disease current status |
| topic | autoimmune disease immunotherapy antigen diabetes rheumatoid arthritis multiple sclerosis |
| url | https://www.dovepress.com/antigen-based-immunotherapy-for-autoimmune-disease-current-status-peer-reviewed-article-ITT |
| work_keys_str_mv | AT hirschdl antigenbasedimmunotherapyforautoimmunediseasecurrentstatus AT pondap antigenbasedimmunotherapyforautoimmunediseasecurrentstatus |