Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.

Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 boun...

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Bibliographic Details
Main Authors: Matthew D Neal, Hongpeng Jia, Benjamin Eyer, Misty Good, Christopher J Guerriero, Chhinder P Sodhi, Amin Afrazi, Thomas Prindle, Congrong Ma, Maria Branca, John Ozolek, Jeffrey L Brodsky, Peter Wipf, David J Hackam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3680486?pdf=render

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