The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta
Background: Despite a large number of patients requiring dialysis, the etiology of kidney failure is poorly documented in Indonesia. With the aim to reduce the disease burden, it is essential to obtain more insight in the etiology of chronic kidney disease (CKD). Objective(s): In the present study,...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2023-06-01
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| Series: | Annals of Global Health |
| Subjects: | |
| Online Access: | https://account.annalsofglobalhealth.org/index.php/up-j-agh/article/view/4071 |
| _version_ | 1797777865378365440 |
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| author | Ni Made Hustrini Endang Susalit Aida Lydia Maruhum Bonar H. Marbun Muhammad Syafiq Yassir Johanes Sarwono Elizabeth Yasmine Wardoyo Jonny Suhardjono Rizki Y. Pradwipa Anitasari Nugraheni Merel van Diepen Joris I. Rotmans |
| author_facet | Ni Made Hustrini Endang Susalit Aida Lydia Maruhum Bonar H. Marbun Muhammad Syafiq Yassir Johanes Sarwono Elizabeth Yasmine Wardoyo Jonny Suhardjono Rizki Y. Pradwipa Anitasari Nugraheni Merel van Diepen Joris I. Rotmans |
| author_sort | Ni Made Hustrini |
| collection | DOAJ |
| description | Background: Despite a large number of patients requiring dialysis, the etiology of kidney failure is poorly documented in Indonesia. With the aim to reduce the disease burden, it is essential to obtain more insight in the etiology of chronic kidney disease (CKD). Objective(s): In the present study, we attempted to investigate the primary renal disease of kidney failure patients from five tertiary-care centers in Jakarta. Methods: This is a multicenter, cross-sectional study of kidney failure patients receiving kidney replacement therapy (KRT), from December 2021 to July 2022. We recruited patients aged ≥18 years, had been receiving dialysis for at least three months or a kidney transplantation. Findings: This study included 1,152 patients treated with hemodialysis (68.1%), peritoneal dialysis (7.5%), and kidney transplantation (24.4%). At the start of KRT, the median (interquartile-range [IQR]) age was 48 [37–58] years with low eGFR (median [IQR]: 5.9 [4.0–8.34] ml/minute/1.73 m2). Hypertension was the main comorbidity (74.2%), followed by diabetes mellitus (30.1%). The major primary kidney disease was diabetic kidney disease (27.2%), followed by glomerulonephritis (13.0%), hypertension (11.5%), and urolithiasis (10.3%). Lupus nephritis was the common underlying etiology of secondary glomerulonephritis (91%). A high rate of unknown cause (31.1%) was also observed. Conclusions: Our results suggest that diabetic kidney disease is the leading cause of kidney failure in Jakarta, followed by glomerulonephritis. This study highlights the need for a better approach on primary prevention of diabetes mellitus as well as to better recognize glomerulonephritis at earlier stage might have a significant impact on reduction of the rate of kidney failure in Indonesia. |
| first_indexed | 2024-03-12T23:09:41Z |
| format | Article |
| id | doaj.art-7ac878bfbe964b8683d293338a125c3b |
| institution | Directory Open Access Journal |
| issn | 2214-9996 |
| language | English |
| last_indexed | 2024-03-12T23:09:41Z |
| publishDate | 2023-06-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Annals of Global Health |
| spelling | doaj.art-7ac878bfbe964b8683d293338a125c3b2023-07-18T07:49:52ZengUbiquity PressAnnals of Global Health2214-99962023-06-01891363610.5334/aogh.407126The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in JakartaNi Made Hustrini0https://orcid.org/0000-0001-7748-550XEndang Susalit1Aida Lydia2https://orcid.org/0000-0001-5689-4304Maruhum Bonar H. Marbun3https://orcid.org/0000-0001-7505-0289Muhammad Syafiq4Yassir5Johanes Sarwono6Elizabeth Yasmine Wardoyo7https://orcid.org/0000-0002-3381-5172Jonny8https://orcid.org/0000-0002-8564-7430Suhardjono9Rizki Y. Pradwipa10Anitasari Nugraheni11Merel van Diepen12https://orcid.org/0000-0003-3211-9500Joris I. Rotmans13https://orcid.org/0000-0001-9682-6234Division of Nephrology and Hypertension – Department of Internal Medicine, Faculty of Medicine – Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, ID; Department of Internal Medicine, Leiden University Medical Center, LeidenDivision of Nephrology and Hypertension – Department of Internal Medicine, Faculty of Medicine – Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, JakartaDivision of Nephrology and Hypertension – Department of Internal Medicine, Faculty of Medicine – Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, JakartaDivision of Nephrology and Hypertension – Department of Internal Medicine, Faculty of Medicine – Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, JakartaDepartment of Internal Medicine, Persahabatan General Hospital, JakartaDepartment of Internal Medicine, Persahabatan General Hospital, JakartaDivision of Nephrology – Department of Internal Medicine, Fatmawati General Hospital, JakartaDivision of Nephrology – Department of Internal Medicine, Fatmawati General Hospital, JakartaDivision of Nephrology, Department of Internal Medicine, Gatot Soebroto Central Army Hospital, JakartaHemodialysis Unit, Pelni General Hospital, JakartaHemodialysis Unit, Pelni General Hospital , JakartaHemodialysis Unit, Pelni General Hospital, JakartaDepartment of Clinical Epidemiology, Leiden University Medical Center, LeidenDepartment of Internal Medicine, Leiden University Medical Center, LeidenBackground: Despite a large number of patients requiring dialysis, the etiology of kidney failure is poorly documented in Indonesia. With the aim to reduce the disease burden, it is essential to obtain more insight in the etiology of chronic kidney disease (CKD). Objective(s): In the present study, we attempted to investigate the primary renal disease of kidney failure patients from five tertiary-care centers in Jakarta. Methods: This is a multicenter, cross-sectional study of kidney failure patients receiving kidney replacement therapy (KRT), from December 2021 to July 2022. We recruited patients aged ≥18 years, had been receiving dialysis for at least three months or a kidney transplantation. Findings: This study included 1,152 patients treated with hemodialysis (68.1%), peritoneal dialysis (7.5%), and kidney transplantation (24.4%). At the start of KRT, the median (interquartile-range [IQR]) age was 48 [37–58] years with low eGFR (median [IQR]: 5.9 [4.0–8.34] ml/minute/1.73 m2). Hypertension was the main comorbidity (74.2%), followed by diabetes mellitus (30.1%). The major primary kidney disease was diabetic kidney disease (27.2%), followed by glomerulonephritis (13.0%), hypertension (11.5%), and urolithiasis (10.3%). Lupus nephritis was the common underlying etiology of secondary glomerulonephritis (91%). A high rate of unknown cause (31.1%) was also observed. Conclusions: Our results suggest that diabetic kidney disease is the leading cause of kidney failure in Jakarta, followed by glomerulonephritis. This study highlights the need for a better approach on primary prevention of diabetes mellitus as well as to better recognize glomerulonephritis at earlier stage might have a significant impact on reduction of the rate of kidney failure in Indonesia.https://account.annalsofglobalhealth.org/index.php/up-j-agh/article/view/4071etiology of kidney failureprimary renal diseasedialysiskidney transplantationmulticenter |
| spellingShingle | Ni Made Hustrini Endang Susalit Aida Lydia Maruhum Bonar H. Marbun Muhammad Syafiq Yassir Johanes Sarwono Elizabeth Yasmine Wardoyo Jonny Suhardjono Rizki Y. Pradwipa Anitasari Nugraheni Merel van Diepen Joris I. Rotmans The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta Annals of Global Health etiology of kidney failure primary renal disease dialysis kidney transplantation multicenter |
| title | The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta |
| title_full | The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta |
| title_fullStr | The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta |
| title_full_unstemmed | The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta |
| title_short | The Etiology of Kidney Failure in Indonesia: A Multicenter Study in Tertiary-Care Centers in Jakarta |
| title_sort | etiology of kidney failure in indonesia a multicenter study in tertiary care centers in jakarta |
| topic | etiology of kidney failure primary renal disease dialysis kidney transplantation multicenter |
| url | https://account.annalsofglobalhealth.org/index.php/up-j-agh/article/view/4071 |
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