A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs
Inappropriate application of antimicrobial agents can result in resistance by bacteria to drugs and changes in bacterial ecology. In particular, the emergence of multi-drug resistant bacteria seriously aff ects the antibacterial effi cacy of drugs, which threatens the health and lives of humans and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2022-02-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=2889 |
| _version_ | 1827922281061416960 |
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| author | Hongjuan WANG Longfei ZHANG Jianhe HU |
| author_facet | Hongjuan WANG Longfei ZHANG Jianhe HU |
| author_sort | Hongjuan WANG |
| collection | DOAJ |
| description | Inappropriate application of antimicrobial agents can result in resistance by bacteria to drugs and changes in bacterial ecology.
In particular, the emergence of multi-drug resistant bacteria seriously aff ects the antibacterial effi cacy of drugs, which threatens the health
and lives of humans and animals. Pharmacokinetic/Pharmacodynamic (PK/PD) models can be used to analyze the relationship between
PK and PD data and the antibacterial eff ect. PK/PD models provide valuable guidance for optimization of dosage regimens, development
of new drugs, setting of susceptibility breakpoints, and analyses of resistant mutants. Th e main models of PK/PD integration are in vitro
PK/PD, ex vivo PK/PD, and in vivo PK/PD. Each of these models has its own advantages and disadvantages. Hence, knowing how to
choose the appropriate PK/PD model has a huge infl uence on obtaining accurate PK/PD data. In this review, we describe the commonly
used PK/PD methods. In this way, we provide a reference for optimizing drug regimens and preventing and controlling drug-resistant
bacterial infections. |
| first_indexed | 2024-03-13T04:39:25Z |
| format | Article |
| id | doaj.art-7ac936f4dcd142fdb74586039a04b053 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:25Z |
| publishDate | 2022-02-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-7ac936f4dcd142fdb74586039a04b0532023-06-19T06:28:22ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512022-02-0128228128910.9775/kvfd.2021.268492889A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugsHongjuan WANG0Longfei ZHANG1Jianhe HU2College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang453003, Henan, P. R. CHINACollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang453003, Henan, P. R. CHINACollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang453003, Henan, P. R. CHINAInappropriate application of antimicrobial agents can result in resistance by bacteria to drugs and changes in bacterial ecology. In particular, the emergence of multi-drug resistant bacteria seriously aff ects the antibacterial effi cacy of drugs, which threatens the health and lives of humans and animals. Pharmacokinetic/Pharmacodynamic (PK/PD) models can be used to analyze the relationship between PK and PD data and the antibacterial eff ect. PK/PD models provide valuable guidance for optimization of dosage regimens, development of new drugs, setting of susceptibility breakpoints, and analyses of resistant mutants. Th e main models of PK/PD integration are in vitro PK/PD, ex vivo PK/PD, and in vivo PK/PD. Each of these models has its own advantages and disadvantages. Hence, knowing how to choose the appropriate PK/PD model has a huge infl uence on obtaining accurate PK/PD data. In this review, we describe the commonly used PK/PD methods. In this way, we provide a reference for optimizing drug regimens and preventing and controlling drug-resistant bacterial infections.https://vetdergikafkas.org/pdf.php?id=2889antibacterial drugspk/pd integration modelmulti-drug resistancedosage regimen optimizationin vivo pk/pd model |
| spellingShingle | Hongjuan WANG Longfei ZHANG Jianhe HU A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs Kafkas Universitesi Veteriner Fakültesi Dergisi antibacterial drugs pk/pd integration model multi-drug resistance dosage regimen optimization in vivo pk/pd model |
| title | A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs |
| title_full | A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs |
| title_fullStr | A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs |
| title_full_unstemmed | A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs |
| title_short | A methodological review on the pharmacokinetic/pharmacodynamic integration of antibacterial drugs |
| title_sort | methodological review on the pharmacokinetic pharmacodynamic integration of antibacterial drugs |
| topic | antibacterial drugs pk/pd integration model multi-drug resistance dosage regimen optimization in vivo pk/pd model |
| url | https://vetdergikafkas.org/pdf.php?id=2889 |
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