Research progress of retinal neurovascular unit injury in glaucoma
Glaucoma is one of the leading causes of vision loss worldwide. More and more studies have suggested that glaucoma is a complicated retinal neurovascular disease. The homeostasis imbalance of retinal neurovascular unit(RNVU)composed of neurons, glial cells and microvascular cells not only induces ch...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-02-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2024/2/202402010.pdf |
| _version_ | 1797352777873096704 |
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| author | Ouyang Lingyi He Tao Xing Yiqiao |
| author_facet | Ouyang Lingyi He Tao Xing Yiqiao |
| author_sort | Ouyang Lingyi |
| collection | DOAJ |
| description | Glaucoma is one of the leading causes of vision loss worldwide. More and more studies have suggested that glaucoma is a complicated retinal neurovascular disease. The homeostasis imbalance of retinal neurovascular unit(RNVU)composed of neurons, glial cells and microvascular cells not only induces changes in microvascular structure and glial cells, but also affects the nerve tissue of the retina, resulting in vision loss, which there is no effective treatment to reverse, currently. Exploring the cellular composition and molecular structure of RNVU and investigating the destruction mechanism of normal cellular environment and intercellular connections in glaucoma are of great significance in exploring the pathogenesis and the treatment of glaucoma. The research progress on structural changes and dysfunction of RNVU in glaucoma are reviewed, hoping to provide new ideas for the treatment of glaucoma. |
| first_indexed | 2024-03-08T13:21:44Z |
| format | Article |
| id | doaj.art-7ac93be520e04fc6a1489813764d9be8 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-08T13:21:44Z |
| publishDate | 2024-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-7ac93be520e04fc6a1489813764d9be82024-01-18T03:35:38ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-02-0124223023510.3980/j.issn.1672-5123.2024.2.10202402010Research progress of retinal neurovascular unit injury in glaucomaOuyang Lingyi0He Tao1Xing Yiqiao2Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, ChinaGlaucoma is one of the leading causes of vision loss worldwide. More and more studies have suggested that glaucoma is a complicated retinal neurovascular disease. The homeostasis imbalance of retinal neurovascular unit(RNVU)composed of neurons, glial cells and microvascular cells not only induces changes in microvascular structure and glial cells, but also affects the nerve tissue of the retina, resulting in vision loss, which there is no effective treatment to reverse, currently. Exploring the cellular composition and molecular structure of RNVU and investigating the destruction mechanism of normal cellular environment and intercellular connections in glaucoma are of great significance in exploring the pathogenesis and the treatment of glaucoma. The research progress on structural changes and dysfunction of RNVU in glaucoma are reviewed, hoping to provide new ideas for the treatment of glaucoma.http://ies.ijo.cn/cn_publish/2024/2/202402010.pdfglaucomaretinal neurovascular unitretinal ganglion cellglial cellmicrovascular cell |
| spellingShingle | Ouyang Lingyi He Tao Xing Yiqiao Research progress of retinal neurovascular unit injury in glaucoma Guoji Yanke Zazhi glaucoma retinal neurovascular unit retinal ganglion cell glial cell microvascular cell |
| title | Research progress of retinal neurovascular unit injury in glaucoma |
| title_full | Research progress of retinal neurovascular unit injury in glaucoma |
| title_fullStr | Research progress of retinal neurovascular unit injury in glaucoma |
| title_full_unstemmed | Research progress of retinal neurovascular unit injury in glaucoma |
| title_short | Research progress of retinal neurovascular unit injury in glaucoma |
| title_sort | research progress of retinal neurovascular unit injury in glaucoma |
| topic | glaucoma retinal neurovascular unit retinal ganglion cell glial cell microvascular cell |
| url | http://ies.ijo.cn/cn_publish/2024/2/202402010.pdf |
| work_keys_str_mv | AT ouyanglingyi researchprogressofretinalneurovascularunitinjuryinglaucoma AT hetao researchprogressofretinalneurovascularunitinjuryinglaucoma AT xingyiqiao researchprogressofretinalneurovascularunitinjuryinglaucoma |