Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
Bioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00007/full |
| _version_ | 1811213502333845504 |
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| author | Baowei Wang Baowei Wang Baowei Wang Zhiwen Wang Zhiwen Wang Zhiwen Wang Tao Chen Tao Chen Tao Chen Xueming Zhao Xueming Zhao Xueming Zhao |
| author_facet | Baowei Wang Baowei Wang Baowei Wang Zhiwen Wang Zhiwen Wang Zhiwen Wang Tao Chen Tao Chen Tao Chen Xueming Zhao Xueming Zhao Xueming Zhao |
| author_sort | Baowei Wang |
| collection | DOAJ |
| description | Bioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physical structure of the control system. After the introduction of digital computers to bioreactor process control, a hierarchical structure control system (HSCS) for bioreactors has become the dominant physical structure, having high efficiency and robustness. However, inherent drawbacks of the HSCS for bioreactors have produced a need for a more consolidated solution of the control system. With the fast progress in sensors, machinery, and information technology, the development of a flat organizational control system (FOCS) for bioreactors based on parallel distributed smart sensors and actuators may provide a more concise solution for process control in bioreactors. Here, we review the evolution of the physical structure of bioreactor control systems and discuss the properties of the novel FOCS for bioreactors and related smart sensors and actuators and their application circumstances, with the hope of further improving the efficiency, robustness, and economics of bioprocess control. |
| first_indexed | 2024-04-12T05:47:46Z |
| format | Article |
| id | doaj.art-7aca38f3aa4b440ebd43481e58582262 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T05:47:46Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-7aca38f3aa4b440ebd43481e585822622022-12-22T03:45:25ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-02-01810.3389/fbioe.2020.00007490924Development of Novel Bioreactor Control Systems Based on Smart Sensors and ActuatorsBaowei Wang0Baowei Wang1Baowei Wang2Zhiwen Wang3Zhiwen Wang4Zhiwen Wang5Tao Chen6Tao Chen7Tao Chen8Xueming Zhao9Xueming Zhao10Xueming Zhao11Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaSynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, ChinaFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaDepartment of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaSynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, ChinaFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaDepartment of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaSynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, ChinaFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaDepartment of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaSynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, ChinaFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, ChinaBioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physical structure of the control system. After the introduction of digital computers to bioreactor process control, a hierarchical structure control system (HSCS) for bioreactors has become the dominant physical structure, having high efficiency and robustness. However, inherent drawbacks of the HSCS for bioreactors have produced a need for a more consolidated solution of the control system. With the fast progress in sensors, machinery, and information technology, the development of a flat organizational control system (FOCS) for bioreactors based on parallel distributed smart sensors and actuators may provide a more concise solution for process control in bioreactors. Here, we review the evolution of the physical structure of bioreactor control systems and discuss the properties of the novel FOCS for bioreactors and related smart sensors and actuators and their application circumstances, with the hope of further improving the efficiency, robustness, and economics of bioprocess control.https://www.frontiersin.org/article/10.3389/fbioe.2020.00007/fullflat organizational control systemsknowledge-based control systemsbioreactorssmart sensorsactuators |
| spellingShingle | Baowei Wang Baowei Wang Baowei Wang Zhiwen Wang Zhiwen Wang Zhiwen Wang Tao Chen Tao Chen Tao Chen Xueming Zhao Xueming Zhao Xueming Zhao Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators Frontiers in Bioengineering and Biotechnology flat organizational control systems knowledge-based control systems bioreactors smart sensors actuators |
| title | Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators |
| title_full | Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators |
| title_fullStr | Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators |
| title_full_unstemmed | Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators |
| title_short | Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators |
| title_sort | development of novel bioreactor control systems based on smart sensors and actuators |
| topic | flat organizational control systems knowledge-based control systems bioreactors smart sensors actuators |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00007/full |
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